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Kidney transplantation in systemic lupus erythematosus: Outcomes and prognosis

Saúl Pampa-Saico¹, Roberto Marcén-Letosa¹, Ana Fernández-Rodríguez¹

¹Servicio de Nefrología, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Hospital Universitario Ramón y Cajal, Madrid, España; Red de Investigación Renal (REDinREN), Madrid, España.

Medicina Clinica

|December 4, 2018

Abstract

Introduction:

The outcome and prognosis of systemic lupus erythematosus (SLE) in long-term kidney transplantation (KT) is variable. The objective of this study was to analyse the survival of the graft and the patient, comparing rates with a control group (primary glomerulonephritis [PGN]).

Materials And Methods:

Forty-three patients receiving a KT with diagnosis of lupus nephritis (LN) and 367 patients with PGN were compared between January 1980 and December 2014. The survival causes of loss and death of the graft and the patient were analysed.

Results:

There were no significant differences between the variables analysed. The graft survival at five years (80% SLE vs. 70% PGN) and 10 years (63% SLE vs. 55% PGN) and the patient at 5 years (90% SLE vs. 90% PGN) and 10 years (76% LES vs. 79% PGN) were similar. Not recurrence of LN was observed in any patient.

Conclusions:

Patients with SLE are similar candidates to KT than that with other immunological kidney diseases. There was no recurrence of the disease in any patient.

Keywords:

Lupus eritematoso sistémico Lupus nephritis Nefropatía lúpica Recidiva de glomerulonefritis Recurrence of glomerulonephritis Systemic lupus erythematosus

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