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Psoriasis and hidradenitis suppurativa: A large-scale population-based study
Khalaf Kridin1, Michal Shani2, Yochai Schonmann2
1Department of Dermatology, Rambam Health Care Campus, Haifa, Israel.
Journal of the American Academy of Dermatology
|December 4, 2018
Summary
Psoriasis patients have a higher prevalence of hidradenitis suppurativa (HS). This study found a significant association between psoriasis and HS, suggesting a potential link between these inflammatory skin conditions.
Area of Science:
- Dermatology
- Epidemiology
- Clinical Research
Background:
- The co-occurrence of psoriasis and hidradenitis suppurativa (HS) has been noted, but a definitive association remains unconfirmed.
- Understanding the relationship between these two chronic inflammatory skin diseases is crucial for patient care.
Purpose of the Study:
- To investigate the association between psoriasis and HS using a large-scale, real-world electronic health database.
- To determine if patients with psoriasis have a higher likelihood of also having HS.
Main Methods:
- A cross-sectional study design was employed.
- Prevalence of HS in patients with psoriasis was compared to age-, sex-, and ethnicity-matched controls.
- A cohort of 68,836 patients with psoriasis and 68,836 controls was analyzed.
Main Results:
- The prevalence of HS was significantly higher in patients with psoriasis (0.3%) compared to controls (0.2%), with an odds ratio of 1.8.
- Multivariate analysis confirmed the association between psoriasis and HS, even after adjusting for smoking, obesity, and other comorbidities (OR, 1.8).
- Patients with both psoriasis and HS were younger and had higher rates of obesity and smoking than those with psoriasis alone.
Conclusions:
- A significant positive association exists between hidradenitis suppurativa and psoriasis.
- Further longitudinal studies are recommended to validate these findings in diverse populations.
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