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Early complicated schistosomiasis in a returning traveller: Key contribution of new molecular diagnostic methods
Simon Bonnefond1, Lieselotte Cnops2, Alexandre Duvignaud1
1Division of Clinical Tropical Medicine, Department for Infectious and Tropical Diseases, Bordeaux University Hospital, Bordeaux, France.
Abstract:
Early schistosomiasis poses a serious diagnostic challenge, because current standard diagnostic techniques based on serology and egg microscopy lack sensitivity at the initial presentation. We report spinal cord neuroschistosomiasis in a traveller developing 6 weeks after exposure. The diagnosis was confirmed by Schistosoma mansoni-targeted real-time PCR in blood and cerebrospinal fluid, before the results of conventional methods became positive. Molecular assays represent a paradigm shift for the difficult diagnosis of early schistosomiasis and related complications.
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