Related Experiment Video
Updated: Feb 1, 2026

Formulating and Characterizing an Exosome-based Dopamine Carrier System
Published on: April 4, 2022
Lamotrigine encapsulated intra-nasal nanoliposome formulation for epilepsy treatment: Formulation design,
Arshiya Praveen1, Mohd Aqil1, Syed Sarim Imam2
1Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard (Deemed University), M. B. Road, New Delhi 110062, India.
Abstract:
The purpose of this study was to develop lamotrigine nanoliposomes (LTG-NLs) for the treatment in seizures. The formulation was prepared using thin film hydration and rehydration method using the phospholipon 90 G, cholesterol and tween 80 as main ingredients. The nanoliposomes were optimized by plucket burman design (PBD) and response surface methodology (RSM) optimization techniques. The optimized LTGNLopt was further characterized for surface morphology, in-vitro release, stability study, confocal laser scanning microscopic (CLSM) study and naso toxicity study. The results showed that LTGNLopt shown nano size with high entrapment and drug release. The ex-vivo permeation study and confocal laser microscopy study confirmed the enhancement in permeation across the goat nasal mucosa. From the study, it was concluded that the independent variables used to optimize the NLs shown significant effect on the dependent variables and consider effective lipid carrier system for intranasal delivery.
Related Concept Videos
Nose and Nasal Cavity
Administering Oxygen by Nasal Cannula
Nasal Cannulas
A nasal cannula is a lightweight tube split into two prongs placed in the nostrils,...
Cartesian Form for Vector Formulation
Resultant Moment: Vector Formulation
The resultant moment of a system of forces can be calculated through vector formulation. For example, if we consider...
Couples: Scalar and Vector Formulation
A couple moment is a rotational force that tends to rotate the steering wheel. The wheel's rotation can either be in a clockwise or anticlockwise direction. The right-hand rule is a helpful method for determining the direction of a couple moment....
Formulating and Validating Nursing Diagnosis I
There are thirteen domains...

