Related Experiment Video
Updated: Feb 1, 2026
Fertility Preservation in Patients with Severe Ovarian Dysfunction
Published on: March 25, 2021
The impact of malignancy on response to ovarian stimulation for fertility preservation: a meta-analysis
Volkan Turan1, Molly M Quinn2, Nurten Dayioglu3
1Yeni Yuzyil University School of Medicine, Department of Obstetrics and Gynecology, Division Reproductive Endocrinology and Infertility, Istanbul, Turkey.
Objective:
To evaluate the impact of cancer diagnosis on response to ovarian stimulation for fertility preservation.
Design:
Meta-analysis.
Setting:
Not applicable.
Patient(S):
An electronic-based search was performed with the use of PubMed until May 2018 limited to English-language articles. In the final analysis, 10 case-controlled retrospective cohort studies were included, comparing ovarian response to stimulation between women with cancer and age-matched healthy women (control group).
Intervention(S):
None.
Main Outcome Measure(S):
Number of total oocytes retrieved, number of mature oocytes, fertilization rate and two pronuclei embryos obtained.
Result(S):
Ten studies that included a total of 713 women with cancer were analyzed in the cancer group (722 cycles), and 1,830 healthy women (1,835 cycles) qualified as controls for the meta-analysis. The pooled results showed no impact of cancer diagnosis on the mean number of total oocytes (P=.517; 95% CI -0.23 to 0.12), mature oocytes (P=.104; 95% CI -0.23 to 0.01), and two pronuclei embryos (P=.136; 95% CI -0.32 to 0.04) and fertilization rates (P=.273; 95% CI -0.29 to 0.183). When the analysis was limited to women with breast cancer diagnosis, there was also no difference in the mean number of total oocytes (P=.812; 95% CI -0.28 to 0.36) and mature oocytes (P=.993; 95% CI -0.16 to 0.16) between the two groups.
Conclusion(S):
This meta-analysis indicates that cancer diagnosis is not associated with reduced response to ovarian stimulation.
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