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Updated: Feb 1, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
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A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

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Platelet Aggregability as a Predictor of Restenosis Following Carotid Endarterectomy

Yuichi Mochizuki1, Tatsuya Ishikawa1, Yasuo Aihara1

  • 1Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|December 4, 2018
PubMed

Insights

Platelet aggregability is a key factor in restenosis after carotid endarterectomy (CEA). Higher platelet aggregability significantly increases the risk of restenosis, suggesting its use in guiding antiplatelet therapy.

Area of Science:

  • Vascular Surgery
  • Cardiology
  • Hematology

Background:

  • Efficacy of antiplatelet drugs post-carotid endarterectomy (CEA) for preventing restenosis is uncertain.
  • Platelet aggregability's role in CEA restenosis requires further investigation.

Purpose of the Study:

  • To determine the association between postoperative restenosis and platelet aggregability in patients undergoing CEA.
  • To evaluate platelet aggregability as a predictor of restenosis after CEA.

Main Methods:

  • Retrospective analysis of 36 CEA patients.
  • Platelet aggregability measured using turbidimetric light-transmission aggregometry with collagen induction.
  • Patients categorized into high- and low-platelet aggregability groups based on scores (10-99).

Main Results:

  • Restenosis observed in 10 (28%) patients.
  • Significantly higher restenosis incidence in the high-platelet aggregability group (50.0%) compared to the low-group (13.6%).
  • High platelet aggregability was a significant predictor of restenosis (OR=6.34, P=.0176).

Conclusions:

  • Platelet aggregability is a valuable metric for predicting and preventing restenosis post-CEA.
  • Platelet aggregability may guide optimal antiplatelet drug dosing strategies.
Abstract

Keywords:
Hema Tracer 313MNSR-IIPlatelet aggregationantiplatelet therapycarotid endarterectomylight transmission aggregometerplatelet function assayrestenosis

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