Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Internal Receptors01:31

Internal Receptors

74.7K
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.7K
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

3.3K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.3K
Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

1.4K
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
1.4K
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

742
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
742
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

1.4K
Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
1.4K
What is Natural Selection?01:32

What is Natural Selection?

129.1K
Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
129.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of HCV infection on male reproductive hormones; a systematic review and meta-analysis.

International journal of impotence research·2026
Same author

Seasonal Variations in Human Semen Parameters: A Systematic Review and Meta-Analysis.

Andrology·2025
Same author

Live microbials to boost Anti-SARS-CoV-2 immunity clinical trial (Live BASIC trial): a triple-blind randomized controlled trial.

Infection·2025
Same author

Decreasing barriers to the utilization of cryopreserved sperm in male cancer survivors: an expert review and guide.

The oncologist·2025
Same author

Epigenetic differences in non-plaque tissues of men with Peyronie's disease.

The journal of sexual medicine·2025
Same author

Evolving medical management of erectile dysfunction: recommendations from the Fifth International Consultation on Sexual Medicine (ICSM 2024).

Sexual medicine reviews·2025
Same journal

Feminist perspectives on labiaplasty: liberation, objectification, or medicalization of normal anatomy?

Sexual medicine reviews·2026
Same journal

Effectiveness of non-pharmacological treatments for sexual difficulties in adults with multiple sclerosis: a systematic review and meta-analysis.

Sexual medicine reviews·2026
Same journal

The interplay between the obsessive-compulsive disorder and sexual function: a systematic review.

Sexual medicine reviews·2026
Same journal

Ancient South Asian traditions and the cultural foundations of sexual medicine: from kāma to clinical care.

Sexual medicine reviews·2026
Same journal

Postoperative impact of pelvic organ prolapse and urinary incontinence surgeries on female sexual function measured by validated instruments: a systematic review and meta-analysis.

Sexual medicine reviews·2026
Same journal

Efficacy and safety of acupuncture for erectile dysfunction: a systematic review and meta-analysis of randomized controlled trials.

Sexual medicine reviews·2026
See all related articles

Related Experiment Video

Updated: Feb 1, 2026

Exploring the Role of Deontic Reasoning and World Knowledge in Wason´s Selection Task
06:08

Exploring the Role of Deontic Reasoning and World Knowledge in Wason´s Selection Task

Published on: July 22, 2025

938

Selective Androgen Receptor Modulators: Current Knowledge and Clinical Applications.

Zachary J Solomon1, Jorge Rivera Mirabal2, Daniel J Mazur3

  • 1Baylor College of Medicine, Houston, TX, USA.

Sexual Medicine Reviews
|December 4, 2018
PubMed
Summary
This summary is machine-generated.

Selective androgen receptor modulators (SARMs) offer anabolic benefits with fewer side effects than steroids. Research indicates potential uses for SARMs in treating conditions like cachexia and hypogonadism.

Keywords:
AndrogensDrug-Related Side Effects and Adverse ReactionsHypogonadismSelective Androgen Receptor Modulators

More Related Videos

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

21.1K
Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum
11:47

Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum

Published on: February 15, 2015

30.2K

Related Experiment Videos

Last Updated: Feb 1, 2026

Exploring the Role of Deontic Reasoning and World Knowledge in Wason´s Selection Task
06:08

Exploring the Role of Deontic Reasoning and World Knowledge in Wason´s Selection Task

Published on: July 22, 2025

938
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

21.1K
Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum
11:47

Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum

Published on: February 15, 2015

30.2K

Area of Science:

  • Pharmacology
  • Endocrinology
  • Oncology

Background:

  • Selective androgen receptor modulators (SARMs) are compounds that selectively activate androgen receptors.
  • SARMs offer anabolic cellular activity with a reduced side effect profile compared to traditional anabolic steroids.
  • Their unique chemical structures dictate differential binding to androgen receptors.

Purpose of the Study:

  • To review the current literature on selective androgen receptor modulators (SARMs).
  • To present the background, mechanisms, clinical applications, risks, and benefits of SARMs.
  • To evaluate the potential of SARMs in various medical conditions.

Main Methods:

  • A comprehensive literature review was conducted using MEDLINE.
  • Search terms included "selective androgen receptor modulator," "hypogonadism," "cachexia," "breast cancer," "benign prostatic hyperplasia," "libido," and "lean muscle mass."
  • Both basic research and clinical studies were included in the review.

Main Results:

  • No U.S. Food and Drug Agency-approved indications for SARMs currently exist.
  • Basic research shows favorable pharmacokinetics and minimal drug interactions for SARMs.
  • Early clinical studies suggest potential benefits of SARMs in treating cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and breast cancer.

Conclusions:

  • SARMs demonstrate significant promise for clinical applications.
  • Potential uses include the safe treatment of cachexia, BPH, hypogonadism, breast cancer, and prostate cancer.
  • Further research and clinical trials are warranted to establish approved indications.