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Recent advances in pharmaceutical dosage forms and devices using additive manufacturing technologies
Christos I Gioumouxouzis1, Christina Karavasili1, Dimitrios G Fatouros1
1Department of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Drug Discovery Today
|December 4, 2018
Summary
Additive manufacturing is revolutionizing pharmaceutical manufacturing, moving beyond one-size-fits-all treatments. This technology impacts the entire drug supply chain, from industry to patients, enhancing drug development and delivery.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Biotechnology
Background:
- Traditional pharmaceutical manufacturing relies on standardized dosage forms, limiting personalized medicine.
- Additive manufacturing (AM), or 3D printing, offers a paradigm shift in drug development and production.
- The pharmaceutical industry is exploring innovative technologies to enhance drug delivery and patient outcomes.
Purpose of the Study:
- To review recent advancements in additive manufacturing for pharmaceutical dosage forms and devices.
- To explore the regulatory landscape for 3D-printed drug products.
- To highlight the impact of AM on the pharmaceutical supply chain.
Main Methods:
- Literature review of recent scientific publications and industry reports on additive manufacturing in pharmaceuticals.
- Analysis of current regulatory guidelines and frameworks for 3D-printed medications.
- Synthesis of information on the application of AM in creating novel drug delivery systems.
Main Results:
- Additive manufacturing enables the creation of complex and personalized dosage forms with tailored release profiles.
- Significant progress has been made in developing 3D-printed tablets, implants, and drug-eluting devices.
- The regulatory environment is evolving to address the unique challenges and opportunities presented by 3D-printed pharmaceuticals.
Conclusions:
- Additive manufacturing represents a transformative technology for the pharmaceutical industry, promising personalized medicine and improved patient care.
- Successful integration of 3D printing requires collaboration between industry, regulatory bodies, and healthcare providers.
- Further research and development are needed to fully realize the potential of AM in revolutionizing drug development and manufacturing.
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