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Prothrombotic state in children with obstructive sleep apnea

Antonia Barceló1, Daniel Morell-Garcia2, Pilar Sanchís3

  • 1Department of Laboratory Medicine, Hospital Universitari Son Espases, Palma de Mallorca, Spain; Institut d'Investigació Sanitària de les Illes Balears (IdISBa), Palma de Mallorca, Spain; CIBER Enfermedades Respiratorias (CibeRes) (CB06/06), Spain.

Sleep Medicine
|December 4, 2018
PubMed

Insights

Obstructive sleep apnea (OSA) in children is linked to increased blood clotting. Key measures of apnea severity and disrupted sleep correlated with changes in clotting factors, suggesting a mechanism for cardiovascular risks.

Area of Science:

  • Pediatric Hematology
  • Sleep Medicine
  • Cardiovascular Research

Background:

  • Obstructive sleep apnea (OSA) is increasingly recognized as a risk factor for cardiovascular diseases.
  • Blood hypercoagulability is a potential mechanism linking OSA to adverse cardiovascular outcomes.
  • Understanding these links in pediatric populations is crucial for early intervention.

Purpose of the Study:

  • To investigate the association between hemostatic parameters and sleep breathing variables in children with suspected OSA.
  • To determine if OSA severity and sleep disruption correlate with specific markers of coagulation.

Main Methods:

  • 152 snoring children underwent polysomnography to diagnose OSA.
  • Blood samples were analyzed for platelet count, plateletcrit, PDW, MPV, PT, aPTT, fibrinogen, and CRP.
  • Statistical analyses controlled for anthropometric factors like age, gender, and BMI z-score.

Main Results:

  • Children with OSA exhibited higher platelet count, plateletcrit, and PDW compared to non-OSA children.
  • Platelet count correlated with minimum SaO2, plateletcrit with time below 90% SaO2, and MPV with the apnea-hypopnea index.
  • PT and aPTT showed correlations with oxygen saturation parameters (mean SaO2, ODI).

Conclusions:

  • Pediatric OSA is associated with enhanced blood coagulability.
  • Apnea severity and sleep disruption are linked to specific clotting factor alterations, independent of common covariates.
  • These findings highlight potential hemostatic pathways contributing to cardiovascular risks in pediatric OSA.
Abstract

Keywords:
Blood coagulation testsObstructive sleep apneaPediatric sleep disorder

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