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Related Experiment Video

Updated: Feb 1, 2026

Sequencing of mRNA from Whole Blood using Nanopore Sequencing

Sequencing of mRNA from Whole Blood using Nanopore Sequencing

Published on: June 3, 2019

Relapsed CLL: sequencing, combinations, and novel agents.

Jennifer R Brown¹

¹CLL Center, Division of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA.

Hematology. American Society of Hematology. Education Program

|December 4, 2018

Summary

This summary is machine-generated.

The optimal treatment for relapsed chronic lymphocytic leukemia (CLL) depends on prior therapy, disease prognosis, and patient health. Targeted therapies like ibrutinib and venetoclax show promise in managing relapsed CLL.

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Area of Science:

Oncology
Hematology
Pharmacology

Background:

Chronic lymphocytic leukemia (CLL) therapy has evolved significantly in recent years.
Selecting treatment for previously treated CLL patients requires careful consideration of prior therapies, remission duration, prognostic factors, and patient comorbidities.

Purpose of the Study:

To review current and emerging therapeutic strategies for previously treated patients with chronic lymphocytic leukemia.
To discuss the role of targeted therapies and novel agents in the relapsed setting of CLL.

Main Methods:

Review of randomized trials and retrospective data on chemoimmunotherapy and targeted therapies in CLL.
Analysis of data on the sequencing of novel agents, including Bruton's tyrosine kinase and phosphatidylinositol 3-kinase δ inhibitors.
Consideration of ongoing clinical trials for combination time-limited therapies.

Main Results:

For patients previously treated with chemoimmunotherapy, targeted therapies offer proven benefits.
Ibrutinib is often the preferred first-line kinase inhibitor, but venetoclax and rituximab present emerging alternatives in the relapsed setting.
Limited but supportive data exist for sequencing venetoclax after kinase inhibitor progression.

Conclusions:

Treatment decisions for relapsed CLL must be individualized based on patient-specific factors and treatment history.
Novel agents and combination therapies are advancing the management of relapsed CLL, aiming for deep and potentially curative remissions.