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Tuberculous meningitis: Challenges in diagnosis and management: Lessons learnt from Prof. Dastur's article published
Manish Modi1, Manoj Kumar Goyal1, Anumiti Jain1
1Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Abstract:
It has been approximately five decades since Dastur et al., published their seminal work on pathology of tuberculous meningitis (TBM). Though most of their findings find relevance in today's era, there is an important difference; these findings can now be replicated during life using modern day technology. In this article, we review the seminal words of Professor Dastur and colleagues, analyse their findings, interpret how these revolutionized our understanding of TBM and highlight their relevance in today's era. We also discuss challenges in the management of TBM, which we continue to face today and the various options required to overcome these challenges.
Insights
Professor Dastur's foundational work on tuberculous meningitis (TBM) pathology remains relevant today. Modern technology allows in-vivo replication of findings, aiding current understanding and management of TBM.
Area of Science:
- Neurology
- Infectious Diseases
- Pathology
Background:
- Tuberculous meningitis (TBM) pathology research was significantly advanced by Dastur et al. approximately 50 years ago.
- Many of Dastur's original findings on TBM pathology retain their significance in contemporary medical understanding.
- Advances in technology now permit in-vivo validation of historical pathological observations.