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Facile Total Synthesis of (+)-Spinoxazine B
Mayuko Iwata1, Motoi Kuwabara1, Akinobu Matsuzawa1
1Department of Synthetic Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University.
Abstract:
Herein we describe a short total synthesis of (+)-spinoxazine B, which inhibits nitric oxide (NO) production in BV-2 microgrial cells. Spinoxazine B is the first example of a natural alkaloid containing an oxazinone-pyrrolidone nucleus, and it is expected to serve as a novel drug lead compound as well as a drug discovery scaffold.
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