Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Indicators02:39

Indicators

60.7K
Certain organic substances change color in dilute solution when the hydronium ion concentration reaches a particular value. For example, phenolphthalein is a colorless substance in any aqueous solution with a hydronium ion concentration greater than 5.0 × 10−9 M (pH < 8.3). In more basic solutions where the hydronium ion concentration is less than 5.0 × 10−9 M (pH > 8.3), it is red or pink. Substances such as phenolphthalein, which can be used to determine the pH of a solution, are...
60.7K
Mechanical Ventilation I: Indication and Settings01:29

Mechanical Ventilation I: Indication and Settings

2.8K
Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
2.8K
Respiratory Assessment: Purpose and Indications01:19

Respiratory Assessment: Purpose and Indications

1.8K
Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
1.8K
Bioequivalence of Drugs: Drugs with Multiple Indications01:09

Bioequivalence of Drugs: Drugs with Multiple Indications

159
The concept of therapeutic equivalence (TE) in drugs with multiple indications is complex. A generic drug may be therapeutically equivalent to a brand-name product for one specific indication, but this doesn't necessarily mean it's equivalent for all other indications. Evidence of TE in one patient group and bioequivalence shown in healthy volunteers can support—but not confirm—TE for other indications. However, definitive proof requires individual clinical studies for each...
159
Chronic Obstructive Pulmonary Disease01:24

Chronic Obstructive Pulmonary Disease

2.5K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.5K
Design Example: Measuring Distance Between Two Points with Obstructions01:10

Design Example: Measuring Distance Between Two Points with Obstructions

399
When measuring distances in areas with physical obstructions, such as a lake in a field, surveyors must employ techniques to calculate accurate lengths without direct line measurements. One effective method is the offset technique, which allows for precise distance estimation over inaccessible stretches.In this scenario, a surveyor must measure a side of an area that crosses a lake. Since the measuring tape cannot span the lake, the surveyor begins by establishing a baseline that aligns with...
399

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lung Transplant Go (LTGO): A Randomized Controlled Trial to Evaluate the Efficacy of a Telerehabilitation Behavioral Exercise Intervention after Lung Transplantation.

International journal of telerehabilitation·2026
Same author

Correspondence: A two-step algorithm for pharmacologic management of COPD: Bridging foundational and personalized medicine.

Respiratory medicine·2026
Same author

Association Between Chronic PM2.5 Exposure and CT-Detected Lung Abnormalities in the SPIROMICS Cohort.

Annals of the American Thoracic Society·2026
Same author

Discriminative Performance and Clinical utility of COPD Exacerbation Categories for Predicting Future Exacerbations.

American journal of respiratory and critical care medicine·2026
Same author

Respiratory mortality per STAR, GOLD, and ERS/ATS COPD severity classification.

Annals of the American Thoracic Society·2026
Same author

The evolving science of ventilation heterogeneity: From pathophysiology to personalized therapeutic approaches.

Respiratory medicine·2026

Related Experiment Video

Updated: Feb 1, 2026

A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction
14:05

A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction

Published on: December 20, 2014

32.2K

New Spirometry Indices for Detecting Mild Airflow Obstruction.

Surya P Bhatt1,2, Nirav R Bhakta3, Carla G Wilson4

  • 1Division of Pulmonary, Allergy and Critical Care Medicine and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL, 35294, USA. sbhatt@uabmc.edu.

Scientific Reports
|December 4, 2018
PubMed
Summary
This summary is machine-generated.

New spirometry metrics derived from curve shapes can detect mild chronic obstructive pulmonary disease (COPD) and lung disease missed by traditional tests. These advanced airflow obstruction measures improve identification of individuals with significant disease burden and mortality risk.

More Related Videos

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment
05:58

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment

Published on: March 11, 2021

5.1K
A Mouse Model of Intestinal Partial Obstruction
07:33

A Mouse Model of Intestinal Partial Obstruction

Published on: March 5, 2018

22.6K

Related Experiment Videos

Last Updated: Feb 1, 2026

A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction
14:05

A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction

Published on: December 20, 2014

32.2K
Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment
05:58

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment

Published on: March 11, 2021

5.1K
A Mouse Model of Intestinal Partial Obstruction
07:33

A Mouse Model of Intestinal Partial Obstruction

Published on: March 5, 2018

22.6K

Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology
  • Medical Diagnostics

Background:

  • Diagnosis of chronic obstructive pulmonary disease (COPD) typically relies on spirometric indices demonstrating airflow obstruction.
  • Traditional spirometry may fail to identify individuals with respiratory symptoms or underlying structural lung disease.
  • Novel analysis of spirometry curve shapes may enhance the detection of mild airflow obstruction and associated lung conditions.

Purpose of the Study:

  • To investigate if analyzing the shape of expiratory spirometry curves can improve the detection of mild airflow obstruction and structural lung disease.
  • To derive and validate new metrics from spirometry curve data and assess their association with established measures of COPD.

Main Methods:

  • Analysis of spirometry data from 8307 participants in the COPDGene study.
  • Derivation of novel airflow obstruction metrics (Parameter D, Transition Point, Transition Distance) from volume-time and flow-volume curves.
  • Regression analyses to test associations between novel metrics, CT-based lung disease measures, respiratory morbidity, and mortality.

Main Results:

  • Significant correlations were found between traditional FEV1/FVC ratio and the novel parameters (Parameter D, Transition Point, Transition Distance).
  • All derived metrics showed significant associations with emphysema, small airway disease, dyspnea, and quality of life.
  • Parameter D was independently associated with all-cause mortality, identifying additional participants with unrecognized disease and greater structural lung burden.

Conclusions:

  • Data points on expiratory spirometry curves can be used to derive indices that reveal airflow obstruction.
  • These novel indices identify additional subjects with COPD and structural lung disease who are considered normal by traditional criteria.
  • This approach offers a more sensitive method for diagnosing and assessing the burden of COPD.