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Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
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Published on: December 18, 2016

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The mTOR pathway in treatment of epilepsy: a clinical update

Jennifer L Griffith1, Michael Wong1

  • 1Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Future Neurology
|December 4, 2018
PubMed

Insights

Drug targets for epilepsy are being explored via the mTOR pathway. mTOR inhibitors show promise in reducing seizures for specific conditions and may offer future epilepsy treatments.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Genetics

Background:

  • Epilepsy affects many patients with drug-resistant seizures.
  • The mTOR pathway is crucial for neuronal function and implicated in epileptogenesis.
  • Hyperactivation of the mTOR pathway is linked to tuberous sclerosis complex and related epilepsies.

Purpose of the Study:

  • To explore the role of the mTOR pathway as a potential drug target for epilepsy.
  • To review the efficacy of mTOR inhibitors in treating drug-resistant epilepsy.

Main Methods:

  • Review of recent clinical trials and scientific literature on mTOR pathway and epilepsy.
  • Analysis of mTOR pathway's role in cellular processes related to epileptogenesis.

Main Results:

  • Clinical trials of mTOR inhibitors in tuberous sclerosis complex demonstrate reduced seizure frequency.
  • The mTOR pathway is a validated target in specific epilepsy syndromes.

Conclusions:

  • mTOR inhibitors are effective in managing seizures in certain mTORpathies.
  • Further research is warranted to assess mTOR inhibitors for diverse epilepsies, potentially as preventative or disease-modifying therapies.
Keywords:
epilepsyeverolimusmTORrapamycinseizuretuberous sclerosis

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