Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Function Tests01:25

Pulmonary Function Tests

816
Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
816
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

435
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
435
Uncertainty in Measurement: Accuracy and Precision03:37

Uncertainty in Measurement: Accuracy and Precision

101.1K
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value. 
101.1K
Levels of Organization01:09

Levels of Organization

140.8K
Biological organization is the classification of biological structures, ranging from atoms at the bottom of the hierarchy to the Earth's biosphere. Each level of the hierarchy represents an increase in complexity that builds upon the previous level.
Molecules Are Composed of Atoms, and Biomolecules Are Assembled from Molecules:
The most basic levels include atoms, molecules, and biomolecules. Atoms, the smallest unit of ordinary matter, are composed of a nucleus and electrons. Molecules...
140.8K
Organic Compounds03:02

Organic Compounds

57.4K
All living things are formed mostly of carbon compounds called organic compounds. The category of organic compounds includes both natural and synthetic compounds that contain carbon. Although a single, precise definition has yet to be identified by the chemistry community, most agree that a defining trait of organic molecules is the presence of carbon as the principal element, bonded to hydrogen and other carbon atoms. However, some carbon-containing compounds such as carbonates, cyanides, and...
57.4K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

1.1K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

STARTER: a stand-alone reconfigurable and translational organ-on-chip platform based on modularity and open design principles.

Lab on a chip·2026
Same author

A workflow integrating organ-on-chip culture and correlative 3D light and electron microscopy for microtissue analysis.

Scientific reports·2025
Same author

Accurate Sizing of Monodisperse Microbubble Suspensions by Optical Attenuation Spectroscopy.

Ultrasound in medicine & biology·2025
Same author

Cytokine-induced memory-like responses in endothelial cells link chronic inflammation to vascular disease risk.

Molecular omics·2025
Same author

Organoids-on-a-chip: microfluidic technology enables culture of organoids with enhanced tissue function and potential for disease modeling.

Frontiers in bioengineering and biotechnology·2025
Same author

Blood-perfused Vessels-on-Chips stimulated with patient plasma recapitulate endothelial activation and microthrombosis in COVID-19.

Lab on a chip·2025

Related Experiment Video

Updated: Feb 1, 2026

Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip
09:46

Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip

Published on: February 17, 2023

2.4K

Personalised organs-on-chips: functional testing for precision medicine.

Albert van den Berg1, Christine L Mummery, Robert Passier

  • 1BIOS/Lab on a Chip, University of Twente, The Netherlands.

Lab on a Chip
|December 4, 2018
PubMed
Summary
This summary is machine-generated.

Personalized organs-on-chips offer tailored drug testing for precision medicine. Overcoming challenges in data access and outcome validation requires collaboration among clinicians, patients, and industry.

More Related Videos

Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance
10:51

Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance

Published on: September 26, 2017

17.0K
Culture of Bladder Cancer Organoids as Precision Medicine Tools
08:39

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Published on: December 28, 2021

5.4K

Related Experiment Videos

Last Updated: Feb 1, 2026

Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip
09:46

Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip

Published on: February 17, 2023

2.4K
Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance
10:51

Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance

Published on: September 26, 2017

17.0K
Culture of Bladder Cancer Organoids as Precision Medicine Tools
08:39

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Published on: December 28, 2021

5.4K

Area of Science:

  • Biotechnology
  • Physiology
  • Pharmacology

Background:

  • Organs-on-chips (OoC) are microfluidic systems mimicking organ physiology.
  • Personalization of OoC involves patient-specific cells, tissues, and data.
  • OoC offer potential for personalized medicine, including drug efficacy and safety assessment.

Purpose of the Study:

  • To explore the potential of personalized organs-on-chips for precision medicine.
  • To identify challenges hindering the clinical implementation of personalized OoC.
  • To propose a collaborative approach for advancing personalized OoC in precision medicine.

Main Methods:

  • Review of existing literature on personalized OoC systems.
  • Analysis of personalization strategies, including cell sources and parameter tuning.
  • Identification of barriers to clinical translation and stakeholder engagement.

Main Results:

  • Personalized OoC can incorporate patient-specific elements for tailored physiological models.
  • Examples include airway, vessel, and lung-on-a-chip systems adapted for individual needs.
  • Current personalized OoC are not yet clinically used for precision medicine.

Conclusions:

  • Major challenges include access to personal samples, health data, and outcome validation.
  • Stakeholder involvement (clinicians, patients, industry) is crucial for transitioning personalized OoC to precision medicine.