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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
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Patterns of failures after surgical resection in olfactory neuroblastoma

Nalee Kim1, Chang Geol Lee1, Eui Hyun Kim2

  • 1Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Journal of Neuro-Oncology
|December 4, 2018
PubMed
Abstract

Insights

Patterns of failure in olfactory neuroblastoma (ONB) depend on surgical approach. Craniofacial resection (CFR) is linked to dura-based metastases, while endoscopic surgery (ENDO) shows locoregional failure. Adjuvant radiotherapy improves outcomes for ONB patients.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Head and Neck Cancer

Background:

  • Olfactory neuroblastoma (ONB) is a rare malignancy.
  • Surgical approaches include craniofacial resection (CFR) and endoscopic surgery (ENDO).
  • Patterns of failure after these surgical approaches require detailed analysis.

Purpose of the Study:

  • To analyze patterns of failure in olfactory neuroblastoma (ONB) patients.
  • To compare failure patterns between craniofacial resection (CFR) and endoscopic surgery (ENDO).
  • To evaluate the impact of adjuvant radiotherapy (RT) on treatment outcomes.

Main Methods:

  • Retrospective review of 28 surgically treated ONB patients (1995-2017).
  • Patients underwent either CFR (n=14) or ENDO (n=14).
  • Post-operative radiotherapy (RT) was administered to 19 patients.

Main Results:

  • 5-year progression-free survival (PFS) was 37.3%; 10-year overall survival was 57.5%.
  • Adjuvant RT significantly improved 5-year PFS (46.7% vs. 19.4%, p=0.01).
  • Dura-based metastases were common after CFR, while locoregional failure (LRF) occurred after ENDO, often salvageable.

Conclusions:

  • Delayed dura-based and neck node metastases are distinct failure patterns in ONB.
  • Surgical approach influences recurrence patterns: CFR associated with dura-based metastases, ENDO with LRF.
  • Adjuvant radiotherapy following surgery significantly improves treatment outcomes for ONB.
Keywords:
Craniofacial resectionEndoscopyHead and neck cancerOlfactory neuroblastomaSurvival

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