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Updated: Feb 1, 2026
MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
Published on: September 3, 2013
Consensus on molecular imaging and theranostics in prostate cancer
Stefano Fanti1, Silvia Minozzi2, Gerald Antoch3
1Nuclear Medicine Division, Policlinico S Orsola, University of Bologna, Bologna, Italy.
Developing guidelines for advanced prostate cancer imaging and radiopharmaceutical treatments is challenging. Experts recommend advanced imaging like MRI and PET-CT, but their clinical impact needs further study.
Area of Science:
- Nuclear Medicine
- Oncology
- Radiology
- Urology
Background:
- Rapid advancements in radiopharmaceutical imaging and treatment for prostate cancer necessitate updated clinical guidelines.
- International experts convened to review current data and clinical experience regarding prostate cancer imaging.
Framework:
- A systematic literature review and a modified Delphi process informed expert consensus.
- Diphosphonate bone scanning and contrast-enhanced CT are less recommended in current guidelines.
Implementation:
- Prostate cancer-targeted positron emission tomography (PET) and magnetic resonance imaging (MRI) are frequently suggested but lack established clinical contexts.
- Gallium-68 (Ga-68) or Fluorine-18 (F-18) prostate-specific membrane antigen (PSMA) PET imaging is gaining acceptance.
- Bone-targeting radiopharmaceuticals like radium-223 (Ra-223) have largely replaced older agents due to survival benefits.
Implications:
- While MRI and PET-CT enhance imaging accuracy, their impact on clinical outcomes requires further investigation.
- Enhanced communication between imagers and clinicians is crucial.
- Multidisciplinary input in clinical trial design is essential for integrating imaging insights into decision-making.
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