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Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
Published on: July 15, 2015
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Hypothermic machine perfusion versus static cold preservation in kidney transplantation
José Ignacio Domínguez1, Martin de Amesti1, Alejandro Majerson2
1Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile.
Medwave
|December 4, 2018
Summary
Hypothermic machine perfusion for kidney allografts likely reduces delayed graft function and may improve graft survival compared to static cold preservation, with no impact on patient survival.
Area of Science:
- Nephrology
- Transplantation Surgery
- Medical Device Technology
Background:
- Optimal kidney allograft preservation is critical for successful kidney transplantation outcomes.
- Current preservation methods include hypothermic machine perfusion (HMP) and static cold preservation (SCP).
- Comparing the efficacy of HMP versus SCP is essential for improving transplant success rates.
Purpose of the Study:
- To systematically compare hypothermic machine perfusion and static cold preservation for kidney allografts.
- To evaluate the impact of preservation methods on graft function, survival, and patient survival.
Main Methods:
- Conducted a comprehensive literature search in Epistemonikos, including MEDLINE, EMBASE, and Cochrane databases.
- Included 10 systematic reviews encompassing 34 primary studies, with 13 randomized controlled trials.
- Performed meta-analysis and utilized the GRADE approach for summarizing findings.
Main Results:
- Hypothermic machine perfusion (HMP) appears to reduce the risk of delayed graft function post-transplant.
- HMP may be associated with a marginal increase in kidney allograft survival rates.
- No significant difference in patient survival was observed between HMP and static cold preservation.
Conclusions:
- Hypothermic machine perfusion is a promising preservation technique for kidney transplantation.
- HMP offers potential benefits in early graft function and long-term graft survival.
- Further research may be warranted to confirm long-term patient survival benefits.
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