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Chronic Pharyngitis01:23

Chronic Pharyngitis

11.9K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
741
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
802
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
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Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

736
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
736
Chronic Obstructive Pulmonary Disease01:24

Chronic Obstructive Pulmonary Disease

2.5K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.5K

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Related Experiment Video

Updated: Feb 1, 2026

Robotic Lateral Pancreaticojejunostomy for Chronic Pancreatitis
08:10

Robotic Lateral Pancreaticojejunostomy for Chronic Pancreatitis

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Omalizumab for chronic rhinosinusitis.

Rocío Brañes1, Andrés Rosenbaum2, Claudio Callejas3

  • 1Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile.

Medwave
|December 4, 2018
PubMed
Summary

Omalizumab, an anti-immunoglobulin E therapy, shows unclear benefits for chronic rhinosinusitis symptoms. Evidence suggests potential frequent adverse effects, warranting caution in its use for this condition.

Keywords:
EpistemonikosGRADEomalizumabChronic rhinosinusitis

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Area of Science:

  • Allergy and Immunology
  • Otolaryngology
  • Pharmacology

Background:

  • Chronic rhinosinusitis (CRS) is a prevalent inflammatory condition affecting nasal passages.
  • Immunoglobulin E (IgE) plays a key role in CRS pathogenesis.
  • Omalizumab, an anti-IgE monoclonal antibody, is a potential therapeutic agent for CRS.

Purpose of the Study:

  • To evaluate the efficacy and safety of omalizumab in treating chronic rhinosinusitis.
  • To synthesize evidence from systematic reviews and primary studies on omalizumab for CRS.

Main Methods:

  • Systematic literature search conducted in Epistemonikos, covering multiple databases.
  • Data extraction from systematic reviews, reanalysis of primary studies, and meta-analysis performed.
  • GRADE approach used to assess the certainty of evidence.

Main Results:

  • Five systematic reviews, including two randomized trials, were identified.
  • The efficacy of omalizumab for nasal polyps, quality of life, well-being, or symptoms remains unclear due to very low certainty evidence.
  • Omalizumab appears to be associated with frequent adverse effects.

Conclusions:

  • Current evidence is insufficient to confirm omalizumab's benefits in chronic rhinosinusitis.
  • The potential for frequent adverse effects necessitates careful consideration.
  • Further high-quality research is needed to clarify omalizumab's role in CRS management.