Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

6.6K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.6K
Molecular Models02:00

Molecular Models

43.7K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
43.7K
The Bohr Model02:18

The Bohr Model

80.9K
Following the work of Ernest Rutherford and his colleagues in the early twentieth century, the picture of atoms consisting of tiny dense nuclei surrounded by lighter and even tinier electrons continually moving about the nucleus was well established. This picture was called the planetary model since it pictured the atom as a miniature “solar system” with the electrons orbiting the nucleus like planets orbiting the sun. The simplest atom is hydrogen, consisting of a single proton as the...
80.9K
Stereotype Content Model02:16

Stereotype Content Model

15.4K
The Stereotype Content Model (SCM) was first proposed by Susan Fiske and her colleagues (Fiske, Cuddy, Glick & Xu, 2002; see also Fiske, 2012 and Fiske, 2017). The SCM specifies that when someone encounters a new group, they will stereotype them based on two metrics: warmth—or that group’s perceived intent, and how likely they are to provide help or inflict harm—and competence—or their ability to carry out that objective. Depending on the warmth-competence...
15.4K
Compartment Models: Two-Compartment Model01:20

Compartment Models: Two-Compartment Model

7.1K
The two-compartment model divides the body into central and peripheral compartments to account for varying blood perfusion rates among organs and tissues, affecting drug distribution. The central compartment includes blood and highly perfused tissues with rapid drug distribution, while the peripheral compartment contains tissues with slower drug distribution. After a single IV bolus dose, the drug concentration is high in plasma and low in tissues. The drug distribution between compartments...
7.1K
Clearance Models: Physiological Models01:09

Clearance Models: Physiological Models

320
Drug clearance is a critical pharmacokinetic process involving the irreversible removal of drugs from the body through various organs over a specified time period. Physiological models are indispensable in determining organ-specific clearance, defined by the proportion of the drug eliminated per unit of time from the organ's blood volume.
The organ's clearance rate depends on the blood flow to the organ and the extraction ratio (E). The extraction ratio describes the organ's...
320

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasma proteins associated with disability and mortality risks in Japanese community-dwelling octogenarians.

GeroScience·2026
Same author

Factors associated with symptom development in bilateral hip dysplasia with comparable acetabular coverage.

International orthopaedics·2026
Same author

Where is acetabular reaming concentrated during total hip arthroplasty for hip osteoarthritis? A computed tomography-based simulation analysis.

International orthopaedics·2026
Same author

Comparable clinical outcomes but increased technical difficulty after total hip arthroplasty following curved intertrochanteric varus osteotomy.

International orthopaedics·2026
Same author

Navigation-assisted transtrochanteric rotational osteotomy for osteonecrosis of the femoral head.

International orthopaedics·2026
Same author

Inhibition of Sclerostin Protected Against Particle-Induced Osteolysis via Activation of Wnt Signaling and Suppression of Osteoclast Function.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2026

Related Experiment Video

Updated: Feb 1, 2026

A Mouse Distraction Osteogenesis Model
04:24

A Mouse Distraction Osteogenesis Model

Published on: November 14, 2018

6.7K

A Mouse Distraction Osteogenesis Model.

Masahito Fujio1, Yusuke Osawa2, Masaki Matsushita2

  • 1Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine; m-fujio@med.nagoya-u.ac.jp.

Journal of Visualized Experiments : Jove
|December 4, 2018
PubMed
Summary
This summary is machine-generated.

Researchers developed a custom distractor for distraction osteogenesis (DO), a bone regeneration technique. This new method successfully achieved significant bone formation in mice tibias, demonstrating its potential for skeletal tissue repair.

More Related Videos

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur
09:26

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur

Published on: October 23, 2017

7.9K
Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
07:35

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

Published on: April 11, 2012

18.8K

Related Experiment Videos

Last Updated: Feb 1, 2026

A Mouse Distraction Osteogenesis Model
04:24

A Mouse Distraction Osteogenesis Model

Published on: November 14, 2018

6.7K
An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur
09:26

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur

Published on: October 23, 2017

7.9K
Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
07:35

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

Published on: April 11, 2012

18.8K

Area of Science:

  • Orthopedics
  • Biomaterials Engineering
  • Regenerative Medicine

Background:

  • Distraction osteogenesis (DO) is a surgical method for skeletal tissue regeneration without cell transplantation.
  • The DO process involves latency, distraction, and consolidation phases for bone healing.
  • Existing DO methods may require further refinement for optimal outcomes.

Purpose of the Study:

  • To develop and evaluate a custom-made acrylic resin distractor for distraction osteogenesis in a murine model.
  • To assess the efficacy of the custom distractor in promoting bone formation within the distraction gap.

Main Methods:

  • A custom distractor was fabricated using acrylic resin rings and an expansion screw, based on silicone impressions.
  • The custom distractor was surgically attached to the tibia of mice using needles and acrylic resin.
  • Distraction was initiated after a 5-day latency period at a rate of 0.2 mm/12 h for 8 days, creating a 3.2 mm gap.
  • Bone formation was evaluated using radiography and histology after a 4-week consolidation period.

Main Results:

  • Successful fabrication and implantation of a custom-made acrylic resin distractor in mice tibias.
  • Radiographic and histological analyses confirmed significant bone formation within the distraction gap.
  • The custom distractor facilitated skeletal tissue regeneration through distraction osteogenesis.

Conclusions:

  • The custom-made acrylic resin distractor is an effective tool for distraction osteogenesis in a murine model.
  • This approach demonstrates a viable method for inducing bone regeneration without cell transplantation.
  • Further research may explore clinical applications of this custom distractor for bone defect repair.