3D bioprinting of hydrogel-based biomimetic microenvironments

Area of Science:

• Biomedical Engineering
• Tissue Engineering
• Regenerative Medicine

Background:

• Three-dimensional (3D) bioprinting offers precise control over cell and biomaterial placement for tissue fabrication.
• Significant challenges remain in creating functional human tissues/organs for clinical use via 3D bioprinting.
• The development of biomimetic microenvironments is crucial for overcoming these challenges.

Purpose of the Study:

• To review advances in creating and controlling hydrogel-based biomimetic microenvironments for cell-laden 3D bioprinting.
• To classify these microenvironments based on their physical, chemical, and biological features.
• To discuss the future outlook of 3D bioprinting for biomimetic microenvironment development.

Main Methods:

• Review of current literature on 3D bioprinting and biomimetic microenvironments.
• Classification of hydrogel-based microenvironments by physical, chemical, and biological properties.
• Analysis of strategies for controlling these microenvironments in 3D bioprinting.

Main Results:

• 3D printing enables the creation of structures that mimic native tissues.
• Hydrogel-based biomimetic microenvironments can be tailored through physical, chemical, and biological modifications.
• Advances in controlling these features are key to improving 3D bioprinting outcomes.

Conclusions:

• Hydrogel-based biomimetic microenvironments are essential for advancing 3D bioprinting.
• Further research into controlling microenvironment features will enhance the fabrication of functional tissues.
• This field holds significant promise for future clinical applications in tissue and organ regeneration.