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Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Cardiomyopathy II: Dilated Cardiomyopathy01:30

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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

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Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
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Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
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Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
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Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...
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Right ventricular involvement in hypertrophic cardiomyopathy: Patterns and implications.

Kalliopi Keramida1, George Lazaros1, Petros Nihoyannopoulos2

  • 1Unit of Inherited Cardiovascular Diseases/Heart Center of the Young and Athletes, First Department of Cardiology, Hippokration General Hospital, National and Kapodistrian University of Athens, Greece.

Hellenic Journal of Cardiology : HJC = Hellenike Kardiologike Epitheorese
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PubMed
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Hypertrophic cardiomyopathy (HCM) often affects the right ventricle (RV), causing subtle yet significant changes. Routine RV assessment is crucial for managing HCM patients and improving prognosis.

Keywords:
Hypertrophic cardiomyopathyPrognosisRight ventricular involvementSudden cardiac death

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Area of Science:

  • Cardiology
  • Genetics
  • Pathology

Background:

  • Hypertrophic cardiomyopathy (HCM) is a common inherited heart disease.
  • Current diagnostic criteria and research predominantly focus on the left ventricle.
  • Right ventricular (RV) involvement in HCM is often overlooked but clinically significant.

Purpose of the Study:

  • To highlight the structural and functional changes in the right ventricle in HCM patients.
  • To emphasize the prognostic implications of RV involvement.
  • To advocate for routine inclusion of RV assessment in HCM evaluation.

Main Methods:

  • Review of existing literature on RV involvement in HCM.
  • Analysis of histological findings and pathogenetic mechanisms.
  • Evaluation of echocardiographic indices, including global longitudinal strain.

Main Results:

  • RV involvement in HCM presents with variable hypertrophy and potential dynamic obstruction.
  • Subtle systolic dysfunction is detected by impaired global longitudinal strain, not classical indices.
  • Diastolic dysfunction is evident, linked to fibrosis and impaired RV filling.
  • RV involvement correlates with increased arrhythmias, heart failure, and sudden cardiac death risk.

Conclusions:

  • Right ventricular changes are integral to HCM pathophysiology and prognosis.
  • Standard echocardiography may underestimate RV dysfunction; advanced techniques like strain imaging are valuable.
  • Comprehensive RV assessment is essential for accurate HCM diagnosis and management.