Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Design Example: Analyzing Capacity Contours for Flood Risk Assessment01:17

Design Example: Analyzing Capacity Contours for Flood Risk Assessment

325
Flood risk assessment involves careful planning and analysis to ensure the safety of communities near water retention structures. Capacity contours are a vital tool in this process, as they illustrate the potential spread of water at specific levels in a given area. In the context of building a bund across a small valley, these contours play a critical role in evaluating the safety of nearby residential areas.In this example, the bund is intended to store stormwater in the valley. The engineers...
325
Relative Risk01:12

Relative Risk

2.1K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.1K
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

978
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
978
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

13.5K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.5K
Assessment of the Mouth01:26

Assessment of the Mouth

1.2K
A thorough mouth assessment, including inspection and palpation of the lips, gums, tongue, tonsils, uvula, and pharynx, is crucial in detecting potential health issues. Diseases ranging from oral cancer to systemic conditions like diabetes could be identified early through careful oral examination. This article provides a detailed guide on conducting a comprehensive mouth assessment.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
1.2K
Assessment of Respiration01:23

Assessment of Respiration

2.0K
The respiratory system's basic structures and primary functions lay the foundation for nurses' comprehensive respiratory assessments. This assessment includes subjective and objective data to gauge the patient's respiratory health.
Subjective Assessment: Nurses interview the patient to gather information directly during the subjective assessment. It includes questions about the individual's medical history, medications, and symptoms, focusing on past respiratory conditions like...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of the safety and potential genotoxicity of a high-purity mogroside ingredient containing siamenoside I produced from a modified strain of <i>Yarrowia lipolytica</i>.

Toxicology reports·2026
Same author

Comparative <i>in vitro</i> Metabolism of Siamenoside I and Monk Fruit Extract.

International journal of toxicology·2026
Same author

Chemical-specific adjustment factors (inter-species toxicokinetics) to establish the ADI for monosodium glutamate (MSG).

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2026
Same author

Management of serious <i>Staphylococcus aureus</i> infections in children: A survey of paediatric infectious diseases physicians in Canada.

Paediatrics & child health·2026
Same author

Letter: Using Artificial Intelligence to Identify Three Presenting Phenotypes of Chiari Type 1 Malformation and Syringomyelia.

Neurosurgery·2026
Same author

Middle Childhood Morbidity in Children Born Preterm: A Canadian Cohort Study.

The Journal of pediatrics·2026

Related Experiment Video

Updated: Feb 1, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

88.0K

Risk Assessment Paradigm for Glutamate.

Ashley Roberts1, Barry Lynch1, Ivonne M C M Rietjens2

  • 1Intertek Scientific and Regulatory Consultancy Health, Environmental and Regulatory Services (HERS), Mississauga, Ontario, Canada.

Annals of Nutrition & Metabolism
|December 4, 2018
PubMed
Summary

The European Food Safety Authority (EFSA) proposed a low acceptable daily intake (ADI) for glutamate. New research indicates a significantly higher ADI is safe, based on reproductive toxicity and kinetic data.

Keywords:
Acceptable daily intakeGlutamateMacronutrientRisk assessment

More Related Videos

Assessment of Stress Effects on Cognitive Flexibility using an Operant Strategy Shifting Paradigm
07:26

Assessment of Stress Effects on Cognitive Flexibility using an Operant Strategy Shifting Paradigm

Published on: May 4, 2020

4.0K
Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies &#8212; Genetic Models and Behavioral Tests
08:30

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests

Published on: September 6, 2024

2.6K

Related Experiment Videos

Last Updated: Feb 1, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

88.0K
Assessment of Stress Effects on Cognitive Flexibility using an Operant Strategy Shifting Paradigm
07:26

Assessment of Stress Effects on Cognitive Flexibility using an Operant Strategy Shifting Paradigm

Published on: May 4, 2020

4.0K
Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies &#8212; Genetic Models and Behavioral Tests
08:30

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests

Published on: September 6, 2024

2.6K

Area of Science:

  • Food safety assessment
  • Toxicology
  • Nutritional science

Background:

  • The European Food Safety Authority (EFSA) re-evaluated glutamate, proposing a group acceptable daily intake (ADI) of 30 mg/kg body weight/day.
  • This proposed ADI is lower than typical dietary intake levels and can be exceeded by infants.
  • EFSA's safety assessment relied on a developmental toxicity study not widely used by global regulatory bodies.

Purpose of the Study:

  • To re-evaluate the safety of glutamate intake.
  • To determine a scientifically supported acceptable daily intake (ADI) for glutamate.
  • To address discrepancies in EFSA's safety assessment methodology.

Main Methods:

  • A 3-generation reproductive toxicity study in mice, including detailed brain histopathology.
  • Analysis of toxicokinetic data to assess interspecies differences.
  • Comparison of EFSA's chosen study with alternative data and regulatory practices.

Main Results:

  • A 3-generation reproductive toxicity study showed no adverse effects up to 6,000 mg/kg body weight/day, serving as a robust point of departure.
  • Toxicokinetic data suggest a reduced uncertainty factor for interspecies differences (25 instead of 100).
  • These findings support an ADI of at least 240 mg/kg body weight/day.

Conclusions:

  • The previously established "not specified" ADI for glutamate remains scientifically justified.
  • EFSA's proposed ADI of 30 mg/kg body weight/day is overly conservative and not supported by comprehensive data.
  • A higher ADI for glutamate is warranted based on robust reproductive toxicity and toxicokinetic evidence.