Related Experiment Video

Updated: Feb 1, 2026

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
09:32

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Published on: February 8, 2018

15.5K

Immunoregulation effects of TIM-3 on tumors

C C Sheng1,2, F Y Han1

  • 1Department of Clinical Laboratory, The Second Hospital of Shandong University, Jinan, China.

Neoplasma
|December 5, 2018
PubMed

Insights

Tumor suppressor TIM-3 (T-cell immunoglobulin and mucin-domain containing-3) impacts immune cell function and tumor development. Understanding its role in liver, gastric, and prostate cancers offers new immunotherapy targets.

Area of Science:

  • Immunology
  • Oncology
  • Cancer Research

Background:

  • Cancer is a leading cause of death with increasing incidence.
  • Cancer patients exhibit immune dysfunction and reduced anti-tumor immunity.
  • Immune factors critically influence tumor cell survival and expansion.

Purpose of the Study:

  • To investigate the role of TIM-3 (T-cell immunoglobulin and mucin-domain containing-3) in regulating immune cells within the tumor microenvironment.
  • To analyze TIM-3 expression and its mechanisms in liver, gastric, and prostate cancers.
  • To explore TIM-3's regulatory impact on tumor immunity for novel immunotherapy strategies.

Main Methods:

  • Focus on the regulatory functions of TIM-3 on various immune cells.
  • Examination of TIM-3 expression patterns in specific cancer types (liver, gastric, prostate).
  • Analysis of the underlying molecular mechanisms of TIM-3 in tumor development.

Main Results:

  • TIM-3 is widely expressed across diverse immune cells.
  • TIM-3 modulates both innate and adaptive immune responses.
  • TIM-3's activity is linked to tumor occurrence and progression.

Conclusions:

  • TIM-3 plays a significant role in regulating anti-tumor immunity.
  • TIM-3's involvement in liver, gastric, and prostate cancers highlights its potential as a therapeutic target.
  • Further research into TIM-3 mechanisms can yield new avenues for cancer immunotherapy.

More Related Videos

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs10:13

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs

Published on: November 8, 2024

2.9K
Author Spotlight: Quantification of Complex Lipidomic Samples Using Stable Isotope Labeling07:12

Author Spotlight: Quantification of Complex Lipidomic Samples Using Stable Isotope Labeling

Published on: August 23, 2024

1.8K

Related Concept Videos

Buffer Effectiveness02:19

Buffer Effectiveness

Buffer solutions do not have an unlimited capacity to keep the pH relatively constant . Instead, the ability of a buffer solution to resist changes in pH relies on the presence of appreciable amounts of its conjugate weak acid-base pair. When enough strong acid or base is added to substantially lower the concentration of either member of the buffer pair, the buffering action within the solution is compromised.
The buffer capacity is the amount of acid or base that can be added to a given volume...
55.2K
Framing Effects03:26

Framing Effects

Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in...
7.9K
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH301:11

ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3

All ortho–para directors, excluding halogens, are activating groups. These groups donate electrons to the ring, making the ring carbons electron-rich. Consequently, the reactivity of the aromatic ring towards electrophilic substitution increases. For instance, the nitration of anisole is about 10,000 times faster than the nitration of benzene. The electron-donating effect of the methoxy group in anisole activates the ortho and para positions on the ring and stabilizes the corresponding...
7.5K
Biological Effects of Radiation02:59

Biological Effects of Radiation

All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
17.9K
Piaget's Stage 3 of Cognitive Development01:17

Piaget's Stage 3 of Cognitive Development

During Piaget's concrete operational stage, from ages 7 to 11, children exhibit a marked increase in logical thinking skills, specifically in relation to tangible, real-world events. This stage is characterized by the development of several essential cognitive concepts, including conservation, reversibility, and classification, all of which support the child's evolving capacity for structured thought.
Conservation and Constancy of Quantity
A significant cognitive milestone in the...
1.1K
Effects of feedback01:24

Effects of feedback

Feedback in control systems plays a critical role in shaping various operational parameters, extending beyond simple error reduction to influence stability, bandwidth, gain, impedance, and sensitivity. Understanding these effects requires examining a basic feedback system characterized by defined input, output, error, and feedback signals.
Feedback significantly modifies the gain of a control system. The gain of a system without feedback is altered by a factor of one plus GH, where G represents...
1.0K