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The STRIPAK complex components FAM40A and FAM40B regulate endothelial cell contractility via ROCKs

Narendra Suryavanshi1, Joanna Furmston1, Anne J Ridley2,3

  • 1Randall Centre for Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London, SE1 1UL, UK.

BMC Cell Biology
|December 5, 2018
PubMed
Summary

The FAM40 proteins are crucial for endothelial cell function and vascular integrity. They interact with CCM3, impacting barrier permeability and angiogenesis, suggesting a role in cerebral cavernous malformations (CCM).

Keywords:
Actin cytoskeletonAdherens junctionsCerebral cavernous malformationsEndothelial cellsRho/ROCKSTRIPAK complex

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