Related Experiment Video

Updated: Feb 1, 2026

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy
07:10

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy

Published on: June 18, 2020

22.8K

Development and external validation of a prognostic nomogram for acute decompensation of chronic hepatitis B

Fangyuan Gao1, Xiaoshu Li1, Gang Wan2

  • 1Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China.

BMC Gastroenterology
|December 5, 2018
PubMed

Insights

A new nomogram accurately predicts survival for patients with chronic hepatitis B cirrhosis experiencing acute decompensation. This tool offers superior individualized prognosis compared to existing scoring systems like MELD and CTP.

Area of Science:

  • Hepatology
  • Internal Medicine
  • Medical Prognostics

Background:

  • Acute decompensation (AD) in cirrhosis patients carries a high mortality risk.
  • Chronic hepatitis B (CHB) is a significant cause of cirrhosis worldwide.
  • Accurate prognostic tools are crucial for managing AD in CHB cirrhosis.

Purpose of the Study:

  • To develop and validate a prognostic nomogram for predicting individual survival in patients with acute decompensation of chronic hepatitis B cirrhosis.
  • To compare the nomogram's predictive performance against established scoring systems.

Main Methods:

  • Retrospective development using data from 509 CHB cirrhosis patients with AD.
  • Validation using data from 620 CHB cirrhosis patients with AD.
  • Evaluation of predictive accuracy, discriminative ability, and clinical utility using C-index, calibration curves, and decision curve analysis (DCA).

Main Results:

  • The nomogram incorporated age, previous decompensation, bacterial infection, hepatic encephalopathy, and total bilirubin.
  • It demonstrated a high concordance index (C-index) of 0.897, outperforming CTP, MELD, SOFA, and CLIF-C AD scores.
  • Calibration curves showed good agreement, and DCA indicated superior clinical net benefit compared to other scores.

Conclusions:

  • The developed nomogram provides a more accurate individualized prediction of survival for AD of CHB cirrhosis patients.
  • It surpasses the prognostic capabilities of MELD, CTP, SOFA, and CLIF-C AD scores.
  • This tool can aid clinicians in optimizing patient management and treatment strategies.
Abstract

Keywords:
Chronic hepatitis BChronic liver diseaseNomogramPrognosis

More Related Videos

Establishing a Competing Risk Regression Nomogram Model for Survival Data04:57

Establishing a Competing Risk Regression Nomogram Model for Survival Data

Published on: October 23, 2020

10.9K
Visualization and Analysis of Blood Flow and Oxygen Consumption in Hepatic Microcirculation: Application to an Acute Hepatitis Model10:40

Visualization and Analysis of Blood Flow and Oxygen Consumption in Hepatic Microcirculation: Application to an Acute Hepatitis Model

Published on: August 4, 2012

13.1K

Related Concept Videos

Reliability and Validity01:29

Reliability and Validity

Reliability and validity are two important considerations that must be made with any type of data collection. Reliability refers to the ability to consistently produce a given result. In the context of psychological research, this would mean that any instruments or tools used to collect data do so in consistent, reproducible ways.
13.9K
In Vitro Drug Release Testing: Overview, Development and Validation01:10

In Vitro Drug Release Testing: Overview, Development and Validation

In vitro dissolution and drug release tests assess how quickly and how much of a drug is released from its dosage form into an aqueous medium under standardized laboratory conditions. These tests are essential tools in pharmaceutical development and quality assurance, offering insight into the drug's performance before clinical use.During formulation development, dissolution testing identifies incomplete or inconsistent drug release issues. It also supports decisions on selecting the optimal...
342
Dosage Regimen Designs: Nomograms and Tabulations01:23

Dosage Regimen Designs: Nomograms and Tabulations

Nomograms and tabulations are vital tools used by clinicians to design accurate and individualized dosage regimens. These instruments provide a straightforward method for adjusting dosages based on individual patient characteristics, including age, weight, and physiological condition. The foundation of a drug's nomogram is population pharmacokinetic data collected and analyzed using specific models. This data simplifies complex equations, presenting them diagrammatically or tabularly for easy...
199
Work Done on a System by External Force01:11

Work Done on a System by External Force

The work done by an external force on a particle changes its kinetic energy. However, internal forces must also be considered for a system of interacting particles. The potential energy formulation helps formulate the effect of internal forces. The net work done by an external force can be written in terms of the total change of mechanical energy, which includes both kinetic and potential energies.
In the presence of a non-conservative opposing force, like friction, some part of the work done...
3.0K
Internal and External Forces01:12

Internal and External Forces

Newton's first law states that a net external force causes a change in motion. External forces act on an object or system, originating outside of the object or system. In contrast, internal forces originate inside the system of interest and do not lead to any acceleration. In simpler words, internal forces are forces that act on one part of an object and are exerted by another part of the same object. External forces are forces that act on an object due to some other object. Therefore, when...
16.3K
External and Internal Respiration01:24

External and Internal Respiration

External respiration occurs in the lungs, and it is the first step in the journey of oxygen inside the body. When we inhale, oxygen enters our lungs and diffuses across the thin alveolar membrane. The alveoli are tiny, air-filled sacs that provide a vast surface area for gas exchange. Oxygen in the alveoli has a higher partial pressure (105 mmHg) than in the adjacent pulmonary capillaries (40 mmHg), establishing a pressure gradient. As a result, oxygen molecules move from the alveoli into the...
7.6K