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Area of Science:

  • Immunology
  • Gastroenterology
  • Pulmonology

Background:

  • Common variable immunodeficiency disease (CVID) is the most prevalent primary immunodeficiency in adults.
  • CVID can present with extragastric manifestations, affecting various organ systems.

Observation:

  • A 49-year-old female presented with a complex medical history.
  • She exhibited granulomatous-lymphocytic interstitial lung disease, liver fibrosis, and portal hypertension.
  • Rectal cancer was also diagnosed in this patient.

Findings:

  • Histopathological examination revealed non-necrotic granulomas in the lungs, mediastinal glands, and liver.
  • The patient required consultation across six different medical specialties.
  • The findings underscore the diverse and widespread organ involvement in CVID.

Implications:

  • The multifaceted presentation of CVID necessitates a comprehensive diagnostic approach.
  • Multidisciplinary collaboration is crucial for managing patients with CVID and its associated complications.
  • This case emphasizes the importance of recognizing CVID in adults with unexplained multi-organ involvement.