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Related Experiment Video

Updated: Feb 1, 2026

Author Spotlight: Enhancing Diagnostic Strategies and Biomarker Development for Comprehensive Lung Function Analysis
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A comprehensive approach to lung function in bronchiectasis.

Dejan Radovanovic1, Pierachille Santus1, Francesco Blasi2

  • 1Department of Biomedical and Clinical Sciences (DIBIC), University of Milan, Division of Respiratory Diseases, Ospedale L. Sacco, ASST Fatebenfratelli-Sacco, Milan, Italy.

Respiratory Medicine
|December 5, 2018
PubMed
Summary
This summary is machine-generated.

Simple spirometry is insufficient for bronchiectasis patients. Air trapping and diffusion impairment are common, and bronchodilation reversibility of residual volume (RVrev) indicates worse lung function.

Keywords:
BronchiectasisExacerbationPlethysmographyResidual volumeReversibilitySpirometry

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Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology

Background:

  • Bronchiectasis pathophysiology is complex and not fully understood.
  • Current guidelines recommend simple spirometry, which may not capture the full picture.

Purpose of the Study:

  • To characterize lung function in bronchiectasis patients.
  • To identify distinct functional subgroups within the bronchiectasis population.

Main Methods:

  • A multicenter, prospective observational study of 187 adult bronchiectasis patients.
  • Evaluated lung function using body-plethysmography, bronchodilation testing, and diffusing lung capacity (DLCO).
  • Defined air trapping, hyperinflation, and acute reversibility (FEV1rev, RVrev).

Main Results:

  • Air trapping (70.2%) and impaired DLCO (55.7%) were the most frequent abnormalities.
  • Only 9.7% of patients had normal lung function.
  • Residual volume reversibility (RVrev, 17.6%) was more common than FEV1 reversibility (FEV1rev, 4.3%) and associated with more severe obstruction and air trapping.

Conclusions:

  • Spirometry alone is inadequate for characterizing bronchiectasis lung function.
  • Air trapping and diffusion impairment are primary functional issues.
  • RVrev may be a valuable marker for assessing lung function severity and stratifying patients.