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Association between exhaled carbon monoxide and asthma outcomes in Peruvian children

Amanda A Pereira1, Suzanne L Pollard2, Robert Locke3

  • 1Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, USA.

Respiratory Medicine
|December 5, 2018
PubMed

Insights

Exhaled carbon monoxide (eCO) may help assess asthma control in low-resource settings. Higher eCO levels were linked to increased odds of uncontrolled asthma in children, suggesting its utility as a biomarker.

Area of Science:

  • Pulmonary Medicine
  • Biomarkers
  • Pediatric Asthma

Background:

  • Asthma prevalence is rising in low and middle-income countries.
  • Assessing asthma control is challenging in resource-limited environments.
  • Exhaled carbon monoxide (eCO) levels correlate with asthma severity and treatment response.

Purpose of the Study:

  • To investigate if exhaled carbon monoxide (eCO) levels are elevated in children with asthma in Lima, Peru.
  • To determine the association between eCO levels and asthma control in a low-resource setting.

Main Methods:

  • Compared eCO levels between 248 children with asthma and 221 healthy controls.
  • Used multivariable regression to analyze the odds of asthma and uncontrolled asthma by eCO quartiles.
  • Assessed asthma control using the Asthma Control Test.

Main Results:

  • Children with asthma had higher average adjusted eCO levels (0.56 ppm).
  • Increased eCO quartiles correlated with higher odds of asthma.
  • Higher eCO quartiles were associated with significantly increased odds of partially controlled or uncontrolled asthma.

Conclusions:

  • Exhaled carbon monoxide (eCO) shows potential as an inexpensive biomarker for asthma control.
  • eCO measurement could be particularly valuable in low-resource settings for managing pediatric asthma.
Abstract

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