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Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Obesity and severe asthma.

Hiroki Tashiro1, Stephanie A Shore1

  • 1Department of Environmental Health, Harvard University T.H. Chan School of Public Health, Boston, MA, USA.

Allergology International : Official Journal of the Japanese Society of Allergology
|December 5, 2018
PubMed
Summary
This summary is machine-generated.

Obesity significantly worsens asthma severity and resistance to treatment in children and adults. Understanding obesity

Keywords:
AllergyIL-6InflammationMicrobiomeWeight loss

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Area of Science:

  • Pulmonology and Environmental Health

Background:

  • Obesity is a major global health concern affecting both children and adults.
  • Obesity is linked to increased asthma prevalence, incidence, and severity.
  • Specific severe asthma phenotypes are characterized by obesity.

Purpose of the Study:

  • To describe severe asthma phenotypes where obesity is a defining feature.
  • To review the mechanistic basis of obesity's impact on severe asthma.
  • To discuss the role of lifestyle interventions in managing severe asthma with obesity.

Main Methods:

  • Literature review of severe asthma phenotypes associated with obesity.
  • Analysis of current concepts on the mechanistic links between obesity and severe asthma.
  • Examination of data on dietary, weight loss, and exercise interventions.

Main Results:

  • Obesity-defined severe asthma features include steroid resistance, airway inflammation, and comorbidities.
  • Potential mechanisms involve vitamin D deficiency, systemic inflammation, and microbiome alterations.
  • Diet, weight loss, and exercise show promise in treating severe asthma in obese individuals.

Conclusions:

  • Obesity is a critical factor in severe asthma, influencing its characteristics and treatment response.
  • Further research into the mechanisms underlying obesity's role can unlock novel therapeutic strategies.
  • Lifestyle interventions are important components in the management of severe asthma with obesity.