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Correlation between expression of MMP-9 and MMP-3 in Helicobacter pylori infected patients with different

Nader Bagheri1, Marzieh Sadeghiani1, Ghorbanali Rahimian2

  • 1Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology
|December 5, 2018
PubMed
Abstract

Insights

Matrix metalloproteinase-9 (MMP-9) mRNA levels are elevated in Helicobacter pylori (H. pylori) infected patients, suggesting its role in H. pylori pathogenesis. Peptic ulcer disease may be linked to MMP-9 upregulation.

Area of Science:

  • Gastroenterology
  • Molecular Biology
  • Pathogenesis Research

Background:

  • Helicobacter pylori (H. pylori) infection is a major cause of gastro-duodenal diseases.
  • The role of matrix metalloproteinases (MMPs), specifically MMP-3 and MMP-9, in H. pylori pathogenesis is not fully understood.
  • Virulence factors like cagA and vacA may influence MMP expression in H. pylori-infected gastric mucosa.

Purpose of the Study:

  • To investigate mucosal MMP-3 and MMP-9 mRNA levels in H. pylori-infected patients.
  • To evaluate the impact of H. pylori virulence factors (cagA, vacA) on MMP-3 and MMP-9 expression.
  • To determine the correlation between MMP levels and disease types (gastritis, peptic ulcer disease).

Main Methods:

  • Gastric biopsies were collected from 50 H. pylori-infected and 50 H. pylori-negative individuals.
  • Real-time PCR was used to quantify MMP-3 and MMP-9 mRNA expression levels.
  • PCR analysis identified the presence of cagA and vacA virulence factors.

Main Results:

  • MMP-3 mRNA levels did not differ significantly between H. pylori-positive and negative patients.
  • MMP-3 expression showed no correlation with virulence factors or disease type.
  • MMP-9 mRNA levels were significantly higher in H. pylori-infected patients compared to controls.
  • MMP-9 expression was associated with cagA status and peptic ulcer disease in infected patients.

Conclusions:

  • MMP-9 may play a significant role in the pathogenesis of H. pylori infection.
  • Upregulation of MMP-9, potentially dependent on the cag pathogenicity island (cag PAI), is associated with peptic ulcer disease in H. pylori-infected individuals.
Keywords:
GastritisHelicobacter pyloriMatrix metalloproteinasePeptic ulcer

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