Related Experiment Video
Updated: Feb 1, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
Published on: November 3, 2010
The genetic basis of disease
Maria Jackson1, Leah Marks1, Gerhard H W May2
1School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, U.K.
Abstract:
Genetics plays a role, to a greater or lesser extent, in all diseases. Variations in our DNA and differences in how that DNA functions (alone or in combinations), alongside the environment (which encompasses lifestyle), contribute to disease processes. This review explores the genetic basis of human disease, including single gene disorders, chromosomal imbalances, epigenetics, cancer and complex disorders, and considers how our understanding and technological advances can be applied to provision of appropriate diagnosis, management and therapy for patients.
Related Concept Videos
What is Genetic Engineering?
Genetics of Speciation
What is Population Genetics?
DNA as a Genetic Template
Animal Mitochondrial Genetics
Types of Genetic Transfer Between Organisms

