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Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
Published on: June 10, 2017
TET2 Deficiency Sets the Stage for B-cell Lymphoma
Jennifer R Shingleton1, Sandeep S Dave2
1Cancer Genetics and Genomics Program, Duke Cancer Institute, Center for Genomic and Computational Biology, Duke University, Durham, North Carolina.
Abstract:
TET2 is a well-established tumor suppressor in the context of myeloid malignancies, but its role in lymphoma development has been less clear. In this issue of Cancer Discovery, Dominguez and colleagues report that TET2 function is critical for germinal center exit and plasma cell differentiation, and its deficiency can lead to B-cell lymphoma phenotypes.See related article by Dominguez et al., p. 1632.
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