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Cognitive functioning in patients treated with electroconvulsive therapy.

Lucie Kalisova1, Marketa Kubinova1, Jiri Michalec1

  • 1Department of Psychiatry, First Faculty of Medicine, Charles University, General University Hospital in Prague, Prague, Czech Republic, luciekalisova@seznam.cz.

Neuropsychiatric Disease and Treatment
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Electroconvulsive therapy (ECT) improves cognitive function in patients with severe mental illness, alongside reduced psychopathology. Cognitive deficits improved significantly during and after ECT treatment.

Keywords:
MCCBcognitionelectroconvulsive therapyside effects

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Psychology

Background:

  • Electroconvulsive therapy (ECT) is a modernized and effective treatment for severe mental illnesses.
  • While side effects have decreased, temporary cognitive disturbances can still occur.
  • Cognitive functioning is a key area of concern in ECT treatment.

Purpose of the Study:

  • To assess the impact of electroconvulsive therapy (ECT) on cognitive functioning in patients with severe mental illness.
  • To evaluate cognitive performance changes during and after ECT treatment.
  • To determine the safety and efficacy of ECT concerning cognitive side effects.

Main Methods:

  • Cognitive functioning was assessed using the Montreal Cognitive Assessment (MoCA) and the MATRICS Consensus Cognitive Battery (MCCB).
  • Assessments were conducted at baseline, during, and at 6 weeks post-ECT.
  • Patients with severe and acute mental illness undergoing ECT were included.

Main Results:

  • Patients exhibited baseline cognitive deficits, likely exacerbated by psychopathology.
  • Cognitive function significantly improved during and after ECT, correlating with reduced psychopathology.
  • While improved, cognitive scores remained below control levels, with further gains observed 6 weeks post-treatment.

Conclusions:

  • Electroconvulsive therapy (ECT) is confirmed as a safe and effective treatment for severe mental disorders.
  • ECT treatment leads to significant improvements in cognitive functioning.
  • The study highlights the positive impact of ECT on both psychopathology and cognition.