Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Replication in Eukaryotes02:31

Replication in Eukaryotes

204.8K
Overview
204.8K
Replication in Eukaryotes01:29

Replication in Eukaryotes

17.4K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
17.4K
The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

18.8K
The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
18.8K
Eukaryotic RNA Polymerases00:58

Eukaryotic RNA Polymerases

27.1K
RNA Polymerase (RNAP) is conserved in all animals, with bacterial, archaeal, and eukaryotic RNAPs sharing significant sequence, structural, and functional similarities. Among the three eukaryotic RNAPs, RNA Polymerase II is most similar to bacterial RNAP in terms of both structural organization and folding topologies of the enzyme subunits. However, these similarities are not reflected in their mechanism of action.
All three eukaryotic RNAPs require specific transcription factors, of which the...
27.1K
The Tree of Life - Bacteria, Archaea, Eukaryotes02:40

The Tree of Life - Bacteria, Archaea, Eukaryotes

38.4K
The “tree of life” describes the evolution of life and the evolutionary relationships between organisms. The root of the tree is the common ancestor to all life on Earth. All other species radiate from this point, much like the branches of a tree. The numerous tips of these branches on the tree of life represent every living, or extant, species. Extinct species, which are species that no longer exist, can be found towards the center of the tree. Currently, these organisms, both...
38.4K
Psychodynamic Perspectives on Personality01:27

Psychodynamic Perspectives on Personality

1.6K
The psychodynamic perspective in psychology asserts that most personality functions operate unconsciously, outside of awareness. This means that the motives and emotions driving behavior often remain hidden, automatically buried in the unconscious mind as a defense mechanism to shield us from psychological distress. According to this theory, the unconscious mind contains thoughts, memories, and emotions that are too disturbing to face directly.
Psychodynamic theorists argue that unconscious...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Wireless Bioelectronic Modulation of Membrane Potential in Glioblastoma Using Carbon Nanotube Porins.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Membrane-Inserting α‑Lipid Polymers: Understanding Lipid Membrane Insertion and Effect on Membrane Fluidity.

Chemistry of materials : a publication of the American Chemical Society·2025
Same author

Challenges in the Diagnosis of Biliary Stricture and Cholangiocarcinoma and Perspectives on the Future Applications of Advanced Technologies.

Cancers·2025
Same author

Fusion of liposomes incorporating α-linolenic acid with the cell plasma membrane is site-restricted.

Nanoscale·2025
Same author

A proximity-labeling-based approach to directly detect mRNA delivery to specific subcellular locations.

Molecular therapy. Nucleic acids·2025
Same author

Advancing cancer therapy with custom-built alternating electric field devices.

Bioelectronic medicine·2025

Related Experiment Video

Updated: Feb 1, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

2.4K

New Perspectives on Iron Uptake in Eukaryotes.

Harry G Sherman1, Carolyn Jovanovic2, Snow Stolnik3

  • 1Division of Regenerative Medicine and Cellular Therapies, School of Pharmacy, University of Nottingham, Nottingham, United Kingdom.

Frontiers in Molecular Biosciences
|December 5, 2018
PubMed
Summary

Iron transport across cell membranes is vital for eukaryotic function. This review explores how redox changes and electron transport systems influence iron uptake, particularly non-transferrin bound iron (NTBI), impacting cellular health.

Keywords:
electron transferironnon-transferrin bound ironplasma membrane oxidoreductase systemredoxtransferrintransplasma membrane electron transport systems (tPMETS)

More Related Videos

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
05:08

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Published on: January 31, 2022

5.6K
Perspectives on Neuroscience
26:41

Perspectives on Neuroscience

Published on: July 31, 2007

5.3K

Related Experiment Videos

Last Updated: Feb 1, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

2.4K
Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
05:08

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Published on: January 31, 2022

5.6K
Perspectives on Neuroscience
26:41

Perspectives on Neuroscience

Published on: July 31, 2007

5.3K

Area of Science:

  • Biophysics
  • Biochemistry
  • Cell Biology

Background:

  • Iron is essential for all eukaryotic organisms, and its homeostasis is critical.
  • Dysregulation of iron homeostasis can lead to pathological conditions, including excess non-transferrin bound iron (NTBI).
  • Understanding the link between macroscopic iron transport and redox chemistry is crucial.

Purpose of the Study:

  • To review the biophysical and biochemical processes underlying iron homeostasis.
  • To explore the mechanisms of NTBI uptake and its role in cellular function.
  • To elucidate the thermodynamics and kinetics governing iron transport across membranes.

Main Methods:

  • Literature review of current research on iron homeostasis.
  • Analysis of iron uptake pathways, including transferrin-mediated and non-transferrin mediated processes.
  • Examination of transplasma electron transport systems (tPMETSs) involved in NTBI uptake.

Main Results:

  • NTBI uptake is facilitated by tPMETSs, which also aid in reducing metabolic stress by regenerating NAD(P)H/NAD(P)+ levels.
  • The thermodynamics of iron transport are governed by redox potential cascades and electrochemical behavior of electron transport systems.
  • Kinetic factors, such as membrane dipole changes, influence iron transport across the plasma membrane.

Conclusions:

  • tPMETSs play a dual role in NTBI uptake: detoxification and metabolic regulation.
  • Redox potential and electrochemical gradients are key thermodynamic drivers of iron transport.
  • Membrane dynamics significantly impact the kinetics of cellular iron uptake.