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Combined Treatment with Autologous CIK Cells, Radiotherapy and Chemotherapy in Advanced Cervical Cancer
Ning Li1, Yong-Wei Tian1, Yue Xu1
1The Center of Tumor Diagnosis and Treatment, Kaifeng Central Hospital, No.85 Hedao Street, Longting District, Kaifeng, 475001, Henan, China.
Pathology Oncology Research : POR
|December 5, 2018
Summary
Autologous cytokine-induced killer (CIK) cell therapy combined with radiochemotherapy shows improved short-term efficacy for advanced cervical cancer. This combination therapy enhances immune function and quality of life with minimal side effects compared to radiochemotherapy alone.
Area of Science:
- Oncology
- Immunotherapy
- Cellular Therapy
Background:
- Advanced cervical cancer presents significant treatment challenges.
- Radiochemotherapy is a standard treatment but has limitations in efficacy and quality of life.
- Enhancing immune function is a key strategy to improve cancer treatment outcomes.
Purpose of the Study:
- To evaluate the clinical efficacy of autologous cytokine-induced killer (CIK) cells transfusion combined with radiochemotherapy in advanced cervical cancer.
- To compare therapeutic efficacy, immune function, quality of life, and survival rates between CIK cell combination therapy and standard radiochemotherapy.
- To assess the safety and side effects of the combined treatment approach.
Main Methods:
- A randomized non-blind study involving 89 patients with advanced cervical cancer.
- Patients were divided into a treatment group (autologous CIK cells + radiochemotherapy) and a control group (radiochemotherapy only).
- Evaluations included short-term efficacy, immune markers (CD3+, CD4+/CD8+), quality of life assessments, and survival rates.
Main Results:
- The treatment group demonstrated significantly higher short-term therapeutic efficacy compared to the control group.
- Autologous CIK cell therapy improved peripheral blood CD3+ and CD4+/CD8+ levels, while the control group showed a decrease.
- Patients receiving CIK cell combination therapy reported better quality of life with less functional impairment post-treatment.
Conclusions:
- Autologous CIK cell transfusion combined with radiochemotherapy offers superior short-term efficacy for advanced cervical cancer.
- This combination therapy significantly enhances immune function and improves patient quality of life.
- The combined approach presents a promising, well-tolerated treatment option with reduced side effects compared to radiochemotherapy alone.
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