Related Experiment Video
Updated: Feb 1, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
An assessment of ocular elasticity using real time ultrasound and ocular response analyzer in active or remission
Mehmet Erol Can1, Özlem Unal2, Meltem Ece Kars3
1Department of Ophthalmology, Yuksek Ihtisas Training and Research Hospital, Mimarsinan Mahallesi Emniyet Caddesi Polis Okulu Karşısı, Bursa, Turkey. drm.erolcan@gmail.com.
Purpose:
To investigate the elasticity of ocular structures in patients with rheumatoid arthritis (RA) without ocular involvement.
Methods:
The study included 56 RA patients (study group) and 24 healthy volunteers as the control group. The rheumatoid arthritis patients were divided into two subgroups as those in active phase (Group 1, n = 25) or in remission phase (Group 2, n = 31) according to the disease activity index (DAS 28) score. The elastography values of the ratio of orbital fat-sclera (ROF/S) were measured with real-time US elastography, and corneal mechanical values were measured with the Reichert Ocular Response Analyzer in each eye.
Results:
The mean ROF/S value was 5.2 ± 1.8 in Group 1, 0.7 ± 0.4 Group 2, and 0.6 ± 0.1 in the control group. There was a significant difference between the Group 1 and control group with regard to ROF/S (p < 0.001), but no significant difference was determined between Group 2 and control group (p > 0.05). The mean ROF/S value was a significant difference between the Group 1 and 2 (p < 0.001). ROF/S was significantly correlated with DAS-28 and C-reactive protein (CRP) (r = 0.816, p < 0.001 and r = 0.259, p = 0.006).
Conclusions:
ROF/S was significantly increased in patients in the active phase of RA. Findings revealed that ocular tissue structural changes may occur in the active phase and these could be related to ocular complications as a prognostic factor.
Related Concept Videos
Elastin is Responsible for Tissue Elasticity
Ligaments and tendons are made of dense regular connective tissue, but in ligaments not all fibers are parallel. Dense regular elastic tissue contains elastin fibers and...
Real Time RT-PCR
The real-time quantification of the number of amplified products is...
Elasticity
The elasticity of an object can be described by a stress-strain curve, which represents the relationship between stress...
Assessing Blood pressure using a doppler ultrasound
Pre-Procedural Guidelines for Doppler Ultrasound Blood Pressure Assessment:
Preparation of Equipment:
Elasticity in Concrete
Design Example: Analyzing Capacity Contours for Flood Risk Assessment

