Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

705
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
705
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.5K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.5K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

3.5K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.5K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

236
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
236
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

703
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
703
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

262
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
262

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association between metabolic syndrome and benign prostatic hyperplasia: The underlying molecular connection.

Life sciences·2024
Same author

Recent advances in bacteria-based platforms for inflammatory bowel diseases treatment.

Exploration (Beijing, China)·2024
Same author

Understanding the anti-browning mechanism and physicochemical properties in potato pulp during the magnetic field processing.

Food chemistry·2024
Same author

Can AI generate diagnostic reports for radiologist approval on CXR images? A multi-reader and multi-case observer performance study.

Journal of X-ray science and technology·2024
Same author

Exploring the influence of extruded rice adjunct on wort separation efficiency: A bio-macromolecule degradation perspective.

Food chemistry·2024
Same author

Astral-based DIA proteomics explored the flavor enhancement mechanism of Chinese traditional smoked bacon by staphylococcal co-fermentation.

Food chemistry·2024
Same journal

Effects of OsteoStrong vs. dynamic multicomponent exercise on physical function in older women in the BONEMORE randomized controlled trial.

Aging clinical and experimental research·2026
Same journal

Animal-assisted interventions for depression in older adults: an umbrella review with meta-analysis and trial sequential analysis.

Aging clinical and experimental research·2026
Same journal

Needs, resources, and barriers among family caregivers of people with dementia: a qualitative study.

Aging clinical and experimental research·2026
Same journal

Cross-sectional and longitudinal associations of activity diversity with physical function in community-dwelling older adults.

Aging clinical and experimental research·2026
Same journal

Driving the future of geriatric and musculoskeletal medicine-the continuing ascent of ACER.

Aging clinical and experimental research·2026
Same journal

Perceptions, motivations, needs and experiences of geriatricians with regard to research and research consortia.

Aging clinical and experimental research·2026
See all related articles

Related Experiment Video

Updated: Feb 1, 2026

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans
07:04

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans

Published on: August 15, 2020

5.8K

Selenium, aging and aging-related diseases.

Zhonglin Cai1, Jianzhong Zhang1, Hongjun Li2

  • 1Department of Urology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.

Aging Clinical and Experimental Research
|December 5, 2018
PubMed
Summary
This summary is machine-generated.

Selenium, an essential trace element, plays a role in aging via selenoproteins. While potentially beneficial, its exact role in preventing aging and related diseases remains debated, with low levels possibly being optimal.

Keywords:
AgingAging-related diseaseOxidative stressReactive oxygen speciesSelenium

More Related Videos

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans
11:57

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

9.2K
Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast
10:41

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Published on: August 20, 2013

13.3K

Related Experiment Videos

Last Updated: Feb 1, 2026

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans
07:04

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans

Published on: August 15, 2020

5.8K
Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans
11:57

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

9.2K
Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast
10:41

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Published on: August 20, 2013

13.3K

Area of Science:

  • Biochemistry
  • Gerontology
  • Nutritional Science

Background:

  • Selenium is a vital trace element, integral to selenoproteins with crucial antioxidant functions.
  • Reactive oxygen species are key contributors to aging and associated diseases.
  • Selenoproteins regulate antioxidant activities, impacting cellular health.

Purpose of the Study:

  • To review the current research on selenium's role in human aging.
  • To examine the impact of selenium on age-related diseases.
  • To clarify the controversial effects of selenium supplementation on aging.

Main Methods:

  • Literature review of scientific studies on selenium and aging.
  • Analysis of research on selenoproteins and their antioxidant functions.
  • Evaluation of epidemiological and clinical data regarding selenium levels and age-related conditions.

Main Results:

  • Selenium and selenoproteins exhibit antioxidant properties, potentially mitigating aging factors like inflammation and DNA damage.
  • Selenium supplementation is considered for anti-aging and disease prevention, especially in the elderly.
  • Evidence suggests that the relationship between selenium and aging is complex and potentially dose-dependent, with controversy surrounding optimal levels.

Conclusions:

  • Selenium plays a significant role in cellular antioxidant defense mechanisms relevant to aging.
  • The precise impact of selenium on aging and age-related diseases is still under investigation and debated.
  • Further research is needed to determine optimal selenium intake for healthy aging and disease prevention.