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Melanoma subtypes: genomic profiles, prognostic molecular markers and therapeutic possibilities
Roy Rabbie1,2, Peter Ferguson3,4, Christian Molina-Aguilar5
1Experimental Cancer Genetics, The Wellcome Sanger Institute, Hinxton, UK.
Abstract:
Melanoma is characterised by its ability to metastasise at early stages of tumour development. Current clinico-pathologic staging based on the American Joint Committee on Cancer criteria is used to guide surveillance and management in early-stage disease, but its ability to predict clinical outcome has limitations. Herein we review the genomics of melanoma subtypes including cutaneous, acral, uveal and mucosal, with a focus on the prognostic and predictive significance of key molecular aberrations. © 2018 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
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