Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cancer

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

What is Cancer?

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...

Cancer Prevention

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Validity and utility of blood tumor mutational burden (bTMB) is dependent on circulating tumor DNA (ctDNA) shed: SCRUM-Japan MONSTAR-SCREEN.

The journal of liquid biopsy·2025

Same author

mTOR-mediated p62/SQSTM1 stabilization confers a robust survival mechanism for ovarian cancer.

Cancer letters·2025

Same author

Prognostic significance of para-aortic node metastasis in endometrial cancer: Japanese Gynecologic Oncology Group Study JGOG2043 post hoc analysis.

Journal of gynecologic oncology·2025

Same author

Gut microbiome associated with PARP inhibitor efficacy in patients with ovarian cancer.

Journal of gynecologic oncology·2024

Same author

Low CD86 expression is a predictive biomarker for clinical response to the therapeutic human papillomavirus vaccine IGMKK16E7: results of a post hoc analysis.

JNCI cancer spectrum·2024

Same author

Niraparib in Japanese patients with heavily pretreated, homologous recombination-deficient ovarian cancer: final results of a multicenter phase 2 study.

Journal of gynecologic oncology·2024

Search research articles

Related Experiment Video

Updated: Feb 1, 2026

Stereotactic Radiosurgery for Gynecologic Cancer

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

Warburg effect in Gynecologic cancers.

Yusuke Kobayashi¹, Kouji Banno¹, Haruko Kunitomi¹

¹Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.

The Journal of Obstetrics and Gynaecology Research

|December 5, 2018

Summary

Cancer cells utilize glycolysis for ATP production, known as the Warburg effect. This metabolic shift aids tumor growth and metastasis, presenting a promising therapeutic target in gynecological cancer.

Keywords:

Warburg effect drug repositioning glycolysis oxidative phosphorylation reverse Warburg effect

More Related Videos

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Published on: March 1, 2020

OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery

OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery

Published on: May 9, 2021

Related Experiment Videos

Last Updated: Feb 1, 2026

Stereotactic Radiosurgery for Gynecologic Cancer

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Published on: March 1, 2020

OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery

OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery

Published on: May 9, 2021

Area of Science:

Biochemistry
Oncology
Cancer Metabolism

Background:

Mammalian cells primarily use oxidative phosphorylation for energy.
Otto Warburg observed cancer cells favor glycolysis even with oxygen (Warburg effect).
Glycolysis offers faster ATP production but is less efficient than oxidative phosphorylation.

Purpose of the Study:

To review key players targeted in the Warburg effect.
To outline prospects for Warburg effect-targeted treatments.
Focus on gynecological cancer applications.

Main Methods:

Review of existing literature on the Warburg effect.
Analysis of metabolic pathways in cancer cells.
Exploration of therapeutic targets and strategies.

Main Results:

The Warburg effect supports rapid ATP generation for cancer cells.
It facilitates tumor growth in avascular environments by suppressing oxygen consumption.
Increased lactate production promotes tissue acidosis, aiding cancer invasion and metastasis.

Conclusions:

The Warburg effect is a critical mechanism in cancer development.
Targeting the Warburg effect offers a promising therapeutic strategy.
Further research into targeting this pathway in gynecological cancers is warranted.