Related Experiment Video
Updated: Feb 1, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Metabolic effects of treatment in patients with obstructive sleep apnea: a systematic review
Manuel O Lagravère1, Piero A Zecca2, Alberto Caprioglio3
1Department of Dentistry, University of Alberta, Edmonton, AB, Canada.
Introduction:
Growth retardation was frequently observed in obstructive sleep apnea (OSA) patients but the complex mechanisms causing this condition are still unclear. Several findings suggested growth catch-up after surgical treatment but other studies did not confirm the results, showing no improvement in OSA patients after tonsillectomy and adenoidectomy (T&A). The aim of the present study was to systematically review scientific literature of the relationships between OSA and metabolic changes involving growth hormone (GH) axis before and after treatment in patients.
Evidence Acquisition:
Different databases were searched without limitations up to August 2017. Additionally, the bibliographies of the finally selected articles were hand searched to identify any relevant publications that were not previously identified.
Evidence Synthesis:
From the 37 studies collected from all the databases based on their title and abstract, only 12 studies actually fulfilled the selection criteria. From the twelve finally selected articles, eight focused on growth mediators, two evaluated endothelial mediators, one focused on neurocognitive function and mediators and one focused on local inflammation.
Conclusions:
OSA children present lower levels of growth mediators (IGF-I and IGFBP-3) thus indicating growth retardation, significantly higher cardiovascular disease risk and decreased cognitive functions when compared to controls. T&A seems to improve all the above mentioned functions with great impact on general health.
Related Concept Videos
Sleep Apnea
The condition is more prevalent among...
Pharmacokinetics in Pediatric Patients: Drug Metabolism
Review and Preview
Percentiles are a type of fractile that partition data into...
Review and Preview
Pharmacodynamics in Geriatric Patients: Effects of Age
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

