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Related Experiment Video

Updated: Feb 1, 2026

Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview
06:44

Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview

Published on: May 28, 2007

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Cholera

Renaud Piarroux1, Stanislas Rebaudet2

  • 1Laboratoire de parasitologie et mycologie, groupe hospitalier La-Pitié-Salpêtrière- Charles-Foix, université Pierre-et-Marie-Curie, Paris, France.

La Revue Du Praticien
|December 5, 2018
PubMed
Summary
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Cholera is a severe diarrheal disease caused by Vibrio cholerae bacteria and its toxin. Prompt rehydration is critical for survival, while prevention focuses on sanitation, hygiene, and vaccination.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Cholera is an acute diarrheal illness caused by Vibrio cholerae, a Gram-negative bacterium.
  • Certain strains produce cholera toxin, an enterotoxin responsible for the disease's severe symptoms.
  • The seventh cholera pandemic, originating in 1961 with the V. cholerae O1 El Tor clone, highlights the disease's global impact.

Purpose of the Study:

  • To provide a comprehensive overview of cholera, including its causative agent, pathogenesis, epidemiology, clinical presentation, and prevention strategies.

Main Methods:

  • Literature review of cholera epidemiology, microbiology, and clinical management.
  • Analysis of historical pandemic data and current geographical distribution of cases.
  • Summary of recommended public health interventions and medical treatments.
Keywords:
CholéraMaladies infectieuses

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Last Updated: Feb 1, 2026

Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview
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Quantifying Vibrio cholerae Colonization and Diarrhea in the Adult Zebrafish Model
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Main Results:

  • Vibrio cholerae and its toxin are the primary cause of cholera.
  • Transmission occurs through ingestion of contaminated food or water and close contact with patients.
  • Severe dehydration resulting from toxin-induced intestinal fluid loss is the main determinant of prognosis, with rapid fatality possible without immediate rehydration.

Conclusions:

  • Effective prevention relies on universal access to safe water, sanitation, and hand hygiene.
  • Oral cholera vaccines offer a viable strategy for epidemic control and prevention.
  • Prompt and aggressive rehydration is essential for managing cholera cases and improving survival rates.