Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is a Nervous System?01:25

What is a Nervous System?

104.7K
Overview
104.7K
The Parasympathetic Nervous System01:14

The Parasympathetic Nervous System

115.4K
Overview
115.4K
The Sympathetic Nervous System01:25

The Sympathetic Nervous System

103.6K
Overview
103.6K
The Central Dogma01:25

The Central Dogma

139.8K
Overview
139.8K
The Central Dogma01:20

The Central Dogma

33.8K
The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
33.8K
Nervous System01:21

Nervous System

3.5K
The nervous system coordinates body functions through its complex network of nerve cells, enabling sensation and movement. It is divided into two primary parts: the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS is composed of the brain and the spinal cord. The brain acts as the body's control center, processing sensory information and coordinating responses. The spinal cord functions as a major signaling pathway for the brain and the rest of the body.
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intensified Rituximab, Methotrexate, Procarbazine, and Cytarabine (R-MPVA) Regimen With Sequential Addition of Etoposide to R-MPV and Ifosfamide to R-AraC for Newly Diagnosed Primary CNS Lymphoma Patients Aged Between 60 and 70 Years: An LOC Network Study.

Hematological oncology·2026
Same author

Radiological and FDG-PET imaging features of Epstein-Barr virus-positive primary central nervous system lymphomas.

Journal of neurology·2026
Same author

Temozolomide Versus Radiotherapy as First-Line Therapy for Low-Grade Glioma: Mature Results of a Randomized Phase III Trial (EORTC 22033-26033/NCIC-CTG/TROG/MRC-CTU).

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026
Same author

CAR T-Cell Therapy in Patients With Primary Central Nervous System Lymphoma: A LOC Network Study.

American journal of hematology·2026
Same author

Prognostic factors in adult patients with medulloblastoma.

Neuro-oncology practice·2026
Same author

Early serum S100β but not neuron-specific enolase reflects baseline CNS vulnerability in ICANS after CD19 CAR T-cell therapy.

Journal of neurology·2026

Related Experiment Video

Updated: Feb 1, 2026

Culturing Microglia from the Neonatal and Adult Central Nervous System
11:28

Culturing Microglia from the Neonatal and Adult Central Nervous System

Published on: August 9, 2013

28.9K

[Primary central nervous system lymphoma].

Louis Royer-Perron1, Khê Hoang-Xuan1, Caroline Houillier1

  • 1Assistance publique-Hôpitaux de Paris, Sorbonne universités, service de neurologie Mazarin, groupe hospitalier La Pitié-Salpêtrière, centre de référence LOC, Paris, France.

La Revue Du Praticien
|December 5, 2018
PubMed
Summary

Primary central nervous system lymphoma (PCNSL) is a rare cancer primarily affecting older adults. High-dose methotrexate-based chemotherapy offers a potential cure, with rituximab showing promise.

Keywords:
Lymphome cérébralNeurologie

More Related Videos

Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY
10:28

Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY

Published on: June 30, 2016

14.1K
Isolation of Mononuclear Cells from the Central Nervous System of Rats with EAE
20:51

Isolation of Mononuclear Cells from the Central Nervous System of Rats with EAE

Published on: December 4, 2007

16.8K

Related Experiment Videos

Last Updated: Feb 1, 2026

Culturing Microglia from the Neonatal and Adult Central Nervous System
11:28

Culturing Microglia from the Neonatal and Adult Central Nervous System

Published on: August 9, 2013

28.9K
Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY
10:28

Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY

Published on: June 30, 2016

14.1K
Isolation of Mononuclear Cells from the Central Nervous System of Rats with EAE
20:51

Isolation of Mononuclear Cells from the Central Nervous System of Rats with EAE

Published on: December 4, 2007

16.8K

Area of Science:

  • Neuro-oncology
  • Hematology
  • Immunology

Background:

  • Primary central nervous system lymphoma (PCNSL) is a rare malignancy.
  • While immunosuppression is a risk factor, PCNSL predominantly affects immunocompetent elderly patients.
  • Typical presentation involves the brain, necessitating exclusion of ocular or meningeal involvement.

Purpose of the Study:

  • To summarize the current understanding and management of primary central nervous system lymphoma.
  • To highlight diagnostic considerations and treatment strategies for PCNSL.
  • To emphasize the importance of specialized multidisciplinary care for PCNSL patients.

Main Methods:

  • Review of current literature and clinical guidelines for PCNSL.
  • Analysis of diagnostic approaches, including biopsy and imaging.
  • Evaluation of chemotherapy regimens, including methotrexate-based polychemotherapy and the role of rituximab.

Main Results:

  • PCNSL is highly chemosensitive and potentially curable with high-dose intravenous methotrexate-based polychemotherapy.
  • Adding rituximab may improve outcomes.
  • Relapses are common, and consolidation options like radiotherapy or autologous stem cell transplant are limited by toxicity, especially in older patients.

Conclusions:

  • Early histological diagnosis is crucial; corticosteroids should be delayed until after biopsy.
  • Methotrexate-based chemotherapy is the cornerstone of treatment for PCNSL.
  • Management requires a specialized multidisciplinary team, with expert centers coordinating care.