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Updated: Aug 10, 2026

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice
Published on: August 9, 2013
[Acute renal insufficiency and non-steroidal anti-inflammatory drugs]
J P Ryckelynck1, B Hurault de Ligny, B Levaltier
1Service de Néphrologie, CHU Clémenceau, Caen.
Abstract:
Non-steroid anti-inflammatory drugs cause an increasing number of renal disorders because of their increasing use. In addition to a toxic or immuno-allergic mechanism common to many medications, the side-effects are essentially related to the inhibition of prostaglandins biosynthesis which play a major role as soon as the renal blood flow is compromised. Acute renal failure of hemodynamic origin, interstitial nephropathy with or without nephrotic syndrome are the most characteristic manifestations of the renal toxicity of non-steroid anti-inflammatory drugs.
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