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Updated: Feb 1, 2026
08:25
Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
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Circular RNA involvement in aging: An emerging player with great potential
Hongcai Cai1, Yamin Li1, Jean Damascene Niringiyumukiza1
1Family Planning Research Institute/Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
Mechanisms of Ageing and Development
|December 5, 2018
Summary
Circular RNAs (circRNAs), stable noncoding RNAs, accumulate with age and may drive aging and related diseases. This review explores their role in aging mechanisms and potential therapeutic strategies.
Area of Science:
- Molecular Biology
- Genetics
- Biochemistry
Background:
- Circular RNAs (circRNAs) are novel noncoding RNAs with unique looped structures.
- They exhibit stability, specific expression patterns, and diverse biological functions.
- Recent findings link circRNA accumulation to aging and age-related diseases.
Purpose of the Study:
- To review the advancements in understanding circRNAs in aging.
- To discuss the biogenesis, properties, and functions of circRNAs related to aging.
- To explore the potential role of circRNAs in age-related diseases.
Main Methods:
- Literature review of circRNA research focusing on aging.
- Analysis of circRNA properties, functions, and mechanisms in aging.
- Discussion of circRNA's involvement in specific aging processes and diseases.
Main Results:
- CircRNAs accumulate globally during aging across species.
- CircRNAs influence various aging aspects like neural, muscle, and skin aging.
- They interact with miRNAs and proteins, affecting gene expression at multiple levels.
Conclusions:
- CircRNAs are implicated as causal factors in aging and age-related diseases.
- Their stability and regulatory functions contribute to aging phenotypes.
- Further research into circRNAs offers potential for therapeutic interventions in aging.
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