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Updated: Feb 1, 2026
14:05
A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction
Published on: December 20, 2014
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Reversibility of irreversible aging.
Fedor Galkin1, Bohan Zhang2, Sergey E Dmitriev3
1Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, 119234, Russia; Insilico Medicine, Rockville, Maryland 20850, United States.
Ageing Research Reviews
|December 5, 2018
Summary
Aging is a complex process involving irreversible cell damage. However, reprogramming technologies offer potential for cell rejuvenation and organismal lifespan extension, despite challenges like cancer risk.
Area of Science:
- Gerontology and Regenerative Medicine
- Cell Biology
- Developmental Biology
Background:
- Multicellular organisms undergo aging due to accumulated damage, often involving irreplaceable cells and structures.
- While aging seems irreversible, induced pluripotent stem cells (iPSCs) offer a potential pathway to reverse cellular age.
Purpose of the Study:
- To explore the reconciliation of irreversible aging in some organism parts with the potential for rejuvenation in others.
- To investigate the implications of cell dedifferentiation and reprogramming for organismal lifespan extension.
Main Methods:
- Review of existing literature on aging, cell reprogramming, and regenerative medicine.
- Analysis of the relationship between cellular aging, dedifferentiation, and organismal lifespan.
Main Results:
- Induced pluripotent stem cells (iPSCs) represent a state of cellular youth, suggesting age reversal is possible.
- Reprogramming strategies (in vitro and in vivo) and organ transplantation offer avenues for rejuvenation.
Conclusions:
- Reconciling irreversible aging with cellular rejuvenation holds promise for significant lifespan extension.
- Key challenges include understanding the nature of aging, the organism-part aging relationship, and managing cancer risks associated with rejuvenation.
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