An Iterative Nonlinear Filter Using Variational Bayesian Optimization
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Updated: Feb 1, 2026

Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes
Published on: November 1, 2012
Yumei Hu1,2, Xuezhi Wang3, Hua Lan4,5
1School of Automation, Northwestern Polytechnical University, Xi'an 710072, China. hym@mail.nwpu.edu.cn.
Abstract:
We propose an iterative nonlinear estimator based on the technique of variational Bayesian optimization. The posterior distribution of the underlying system state is approximated by a solvable variational distribution approached iteratively using evidence lower bound optimization subject to a minimal weighted Kullback-Leibler divergence, where a penalty factor is considered to adjust the step size of the iteration. Based on linearization, the iterative nonlinear filter is derived in a closed-form. The performance of the proposed algorithm is compared with several nonlinear filters in the literature using simulated target tracking examples.
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