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Related Concept Videos

GPCR Desensitization01:12

GPCR Desensitization

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G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...
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Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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What is Cancer?02:12

What is Cancer?

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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Related Experiment Video

Updated: Feb 1, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

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GPCR Modulation in Breast Cancer.

Rosamaria Lappano1, Yves Jacquot2, Marcello Maggiolini3

  • 1Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy. lappanorosamaria@yahoo.it.

International Journal of Molecular Sciences
|December 6, 2018
PubMed
Summary

Novel therapies targeting G protein-coupled receptors (GPCRs) show promise for breast cancer treatment. Understanding GPCR signaling is key to overcoming drug resistance in hormone-responsive and triple-negative breast cancer (TNBC).

Keywords:
GPCRsbreast cancersignal transduction

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Related Experiment Videos

Last Updated: Feb 1, 2026

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Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System
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Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System

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Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Breast cancer is a leading cancer in women, with endocrine therapy effective for hormone-responsive subtypes.
  • Triple-negative breast cancer (TNBC) lacks hormone receptors, presents a poor prognosis, and is a significant clinical challenge.
  • Drug resistance is a common issue across all breast cancer subtypes, necessitating novel therapeutic strategies.

Purpose of the Study:

  • To review the role of G protein-coupled receptors (GPCRs) in breast cancer development and progression.
  • To discuss GPCR-mediated signaling pathways, their pharmacological properties, and biological impact on tumorigenesis and metastasis.
  • To identify potential therapeutic opportunities by targeting GPCRs or interfering with GPCR-based signaling in breast cancer.

Main Methods:

  • Literature review and data analysis of GPCRs in breast cancer.
  • Examination of GPCR-mediated signaling pathways involved in breast carcinogenesis, tumor promotion, and metastasis.
  • Evaluation of existing drugs for their potential to modulate GPCR activity in breast cancer.

Main Results:

  • GPCRs are extensively involved in the development and progression of various tumors, including breast cancer.
  • GPCR signaling influences key processes such as breast cancer cell growth, survival, and metastasis.
  • Several drugs have demonstrated potential in interfering with GPCR-driven breast cancer signaling pathways.

Conclusions:

  • Targeting GPCRs represents a promising avenue for developing novel breast cancer therapies.
  • Understanding GPCR signaling is crucial for overcoming therapeutic resistance in both hormone-responsive and triple-negative breast cancer.
  • Further research into GPCR-modulating drugs could lead to improved treatment strategies for breast cancer patients.