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Hyperlipidemia and in vivo hemostatic system activation
J Owen1, B A Grossman, R H Palmer
1Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York.
Seminars in Thrombosis and Hemostasis
|July 1, 1988
Summary
This review suggests ongoing coagulation system activity is unlikely in hyperlipidemia, though episodic bursts may occur. Further research is needed to understand thrombosis in atherogenesis.
Area of Science:
- Cardiovascular Science
- Hematology
- Medical Research
Background:
- Coagulation system activity is a known outcome of advanced atherosclerotic disease.
- The link between coagulation and atherogenesis requires further clarification.
Purpose of the Study:
- To evaluate the association between coagulation system activity and atherogenesis, particularly in individuals with hyperlipidemia.
- To assess the validity of thrombosis-based models of atherogenesis in light of current data.
Main Methods:
- Review and analysis of existing data on coagulation system activity in patients with hyperlipidemia.
- Comparison of findings with established models of atherogenesis.
Main Results:
- Evidence does not support ongoing increased coagulation system activity in individuals with hyperlipidemia.
- The possibility of episodic coagulation activation, potentially missed by current tests, remains.
Conclusions:
- The findings suggest a need to reconsider the time scale of thrombotic events in atherogenesis models.
- A simpler interpretation of coagulation activation in hyperlipidemic patients is possible based on the reviewed data.