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Related Concept Videos

Blind Procedures02:07

Blind Procedures

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Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
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Bioavailability Study Design: Single Versus Multiple Dose Studies01:11

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Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
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Chest Physiotherapy (CPT) is a therapeutic technique used in respiratory care to improve ventilation, clear bronchial secretions, and enhance the efficiency of respiratory muscles. This therapy includes three primary procedures: postural drainage, percussion, and vibration. It can be performed on spontaneously breathing patients and those who are intubated and mechanically ventilated.
Purpose
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Blinding01:11

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Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
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Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

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Body:Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to...
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Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

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Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
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Related Experiment Video

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The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
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Web-based physiotherapy for people affected by multiple sclerosis: a single blind, randomized controlled feasibility

Lorna Paul1, Linda Renfrew2, Jennifer Freeman3

  • 11 School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, UK.

Clinical Rehabilitation
|December 6, 2018
PubMed
Summary

This study found web-based physiotherapy feasible for multiple sclerosis (MS) patients, though no significant improvements were seen in walking or balance. Future trials require 160 participants for adequate power.

Keywords:
InternetPhysiotherapyexercisemultiple sclerosis

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Digital Health

Background:

  • Multiple sclerosis (MS) is a chronic neurological condition impacting mobility and quality of life.
  • Home exercise programs are crucial for managing MS symptoms, but adherence can be challenging.
  • Web-based physiotherapy offers a potential solution to improve accessibility and engagement in rehabilitation.

Purpose of the Study:

  • To assess the feasibility of conducting a trial comparing web-based physiotherapy to standard home exercise programs for individuals with MS.
  • To evaluate participant and physiotherapist acceptance of a novel digital rehabilitation approach.

Main Methods:

  • A multi-center, randomized controlled feasibility study involving 90 participants with MS (Expanded Disability Status Scale 4-6.5).
  • Participants were assigned to either a six-month web-based physiotherapy program or a standard home exercise program.
  • Outcome measures included adherence, functional mobility tests (e.g., two-minute walk test), balance scales, physical activity, and healthcare use, with qualitative interviews for deeper insights.

Main Results:

  • Recruitment feasibility was moderate, with approximately 25% of approached individuals agreeing to participate.
  • Adherence rates ranged from 40%-63% in the intervention group and 53%-71% in the comparator group.
  • No significant differences in functional outcomes, including the two-minute walk test and Berg Balance Scale, were observed between groups over time. The EuroQol-5 Dimension score decreased in the active comparator group at six months.

Conclusions:

  • The web-based physiotherapy intervention was found to be acceptable and feasible for participants and physiotherapists.
  • No significant changes in most outcome measures were detected over the study period.
  • A future randomized controlled trial requires 160 participants to achieve adequate statistical power.